PMID- 9512398
OWN - NLM
STAT- MEDLINE
DCOM- 19980429
LR  - 20120207
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 9
IP  - 3
DP  - 1998 Feb 16
TI  - Differential distribution of TRP Ca2+ channel isoforms in mouse brain.
PG  - 507-15
AB  - Mammalian homologues of the Drosophila TRP proteins, which are essential for 
      light-activated, phosphatidyl-inositide (PI)-dependent Ca2+ conductance in 
      Drosophila photoreceptors, were molecularly identified, to investigate 
      receptor-activated Ca2+ influx in the mammalian nervous system. Two cloned mouse 
      TRP homologues, TRP3 and TRP4, structurally related to the voltage-dependent Na+ 
      channel, were expressed predominantly in the brain, where a sharp contrast in the 
      distribution of the RNA transcripts for TRP isoforms was demonstrated by in situ 
      hybridization analysis. TRP3 mRNA was concentrated in cerebellar Purkinje cells 
      and sparsely localized in the cerebellar granule layer, pontine nuclei, and 
      thalamus, whereas TRP4 mRNA was abundantly expressed in hippocampal CA1 pyramidal 
      neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the 
      septal nuclei and the mitral layer of olfactory bulb. The distinct spatial 
      patterns of TRP isoforms implicate that neurons are highly heterogeneous in 
      receptor-activated Ca2+ influx responsible for the second phase of PI-mediated 
      rise in intracellular Ca2+.
FAU - Mori, Y
AU  - Mori Y
AD  - Department of Information Physiology, National Institute for Physiological 
      Sciences, Okazaki, Japan.
FAU - Takada, N
AU  - Takada N
FAU - Okada, T
AU  - Okada T
FAU - Wakamori, M
AU  - Wakamori M
FAU - Imoto, K
AU  - Imoto K
FAU - Wanifuchi, H
AU  - Wanifuchi H
FAU - Oka, H
AU  - Oka H
FAU - Oba, A
AU  - Oba A
FAU - Ikenaka, K
AU  - Ikenaka K
FAU - Kurosaki, T
AU  - Kurosaki T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Calcium Channels)
RN  - 0 (DNA, Complementary)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (TRPC Cation Channels)
RN  - 0 (TRPC3 cation channel)
RN  - 0 (TRPC4 ion channel)
RN  - 0 (transient receptor potential cation channel, subfamily C, member 1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Brain Chemistry/*physiology
MH  - Calcium Channels/*analysis/genetics
MH  - DNA, Complementary/*genetics
MH  - Genetic Code
MH  - In Situ Hybridization
MH  - Membrane Potentials/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*analysis/genetics
MH  - Sequence Homology, Amino Acid
MH  - TRPC Cation Channels
EDAT- 1998/03/25 00:00
MHDA- 1998/03/25 00:01
CRDT- 1998/03/25 00:00
PHST- 1998/03/25 00:00 [pubmed]
PHST- 1998/03/25 00:01 [medline]
PHST- 1998/03/25 00:00 [entrez]
PST - ppublish
SO  - Neuroreport. 1998 Feb 16;9(3):507-15.