PMID- 9512421
OWN - NLM
STAT- MEDLINE
DCOM- 19980526
LR  - 20190728
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 8
IP  - 6
DP  - 1998 Mar 12
TI  - A distinct role for interleukin-13 in Th2-cell-mediated immune responses.
PG  - 339-42
AB  - Immune responses elicited by allergic reactions and parasitic worm infections are 
      characterised by the induction of T helper 2 (Th2) cells. These cells secrete 
      cytokines such as interleukin-4 (IL-4), IL-5 and IL-13, which induce the 
      production of immunoglobulin E (IgE) and eosinophils [1,2]. Previous studies 
      using gastrointestinal nematodes to elucidate the role of Th2-cell-mediated 
      immune responses have demonstrated a causal relationship between T cells and worm 
      expulsion (reviewed in [3]). Although it has been proposed that IL-4 played a 
      central role in these responses, recent studies demonstrated that IL-4-/- mice 
      expel the parasitic gastrointestinal nematode Nippostrongylus brasiliensis 
      normally [4], suggesting that another T-cell mediator is required for efficient 
      worm clearance. Using IL-13-/- mice, we have demonstrated that, unlike wild-type 
      and IL-4-/- mice, the IL-13-/- animals failed to clear N. brasiliensis infections 
      efficiently, despite developing a robust Th2-like cytokine response to infection. 
      Furthermore, treatment of the IL-13-/- mice with exogenous IL-13 resulted in a 
      reduction in the numbers of worms recovered. The IL-13-/- animals also failed to 
      generate the goblet cell hyperplasia that normally occurs coincident with worm 
      expulsion. This observation may link IL-13 with the production of intestinal 
      mucus which is believed to facilitate worm expulsion. These data support a unique 
      role for IL-13 in Th2-cell-mediated immune responses and demonstrate that IL-13 
      and IL-4 are not redundant.
FAU - McKenzie, G J
AU  - McKenzie GJ
AD  - MRC Laboratory of Molecular Biology, Cambridge, UK.
FAU - Bancroft, A
AU  - Bancroft A
FAU - Grencis, R K
AU  - Grencis RK
FAU - McKenzie, A N
AU  - McKenzie AN
LA  - eng
PT  - Journal Article
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-13)
RN  - 0 (Recombinant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Helminth/isolation & purification
MH  - Carcinoid Tumor/immunology
MH  - Cytokines/isolation & purification
MH  - Immunity, Cellular
MH  - Immunoglobulin A/isolation & purification
MH  - Immunoglobulin E/isolation & purification
MH  - Immunoglobulin G/isolation & purification
MH  - Interleukin-13/administration & dosage/*immunology/isolation & purification
MH  - Intestinal Diseases, Parasitic/immunology/parasitology
MH  - Intestinal Mucosa/immunology
MH  - Lymph Nodes
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nematoda/immunology
MH  - Recombinant Proteins/administration & dosage
MH  - Th2 Cells/*immunology/parasitology
EDAT- 1998/03/25 00:00
MHDA- 1998/03/25 00:01
CRDT- 1998/03/25 00:00
PHST- 1998/03/25 00:00 [pubmed]
PHST- 1998/03/25 00:01 [medline]
PHST- 1998/03/25 00:00 [entrez]
AID - S0960-9822(98)70134-4 [pii]
AID - 10.1016/s0960-9822(98)70134-4 [doi]
PST - ppublish
SO  - Curr Biol. 1998 Mar 12;8(6):339-42. doi: 10.1016/s0960-9822(98)70134-4.