PMID- 9513038
OWN - NLM
STAT- MEDLINE
DCOM- 19980417
LR  - 20161124
IS  - 0914-5087 (Print)
IS  - 0914-5087 (Linking)
VI  - 31
IP  - 2
DP  - 1998 Feb
TI  - [Evaluation of cardiac function by various cardiac imaging techniques in 
      mitochondrial cardiomyopathy: a case report].
PG  - 109-14
AB  - A 39-year-old man with cardiomyopathy due to point mutation of mitochondrial 
      DNA(3243) was admitted to our hospital because of exertional dyspnea accompanied 
      by hearing disturbance and diabetes mellitus. Echocardiography revealed 
      asymmetric hypertrophy of the anterolateral and posterior walls and systolic 
      dysfunction of the left ventricle (fractional shortening = 18%). Pulsed Doppler 
      mitral inflow velocity wave showed a pseudonormalized pattern. Iodine-123 
      betamethyl-p-iodophenyl-pentadecanoic acid (123I-BMIPP) myocardial scintigraphy 
      showed decreased accumulation in the anterolateral, posterior, and apical walls. 
      Left ventriculography showed moderately decreased ejection fraction (43%), and 
      left ventricular end-diastolic pressure was mildly elevated (18 mmHg). 
      Angiography showed normal coronary arteries, but coronary flow reserve measured 
      by administering intravenous adenosine triphosphate was impaired in the left 
      anterior descending and left circumflex arteries compared to the right coronary 
      artery. Intracellular accumulations of abnormal mitochondria were detected by 
      histologic examination of the cardiac and skeletal muscles. Evaluation of cardiac 
      function showed that the area of myocardial hypertrophy was nearly consistent 
      with the region of decrease in 123I-BMIPP accumulation and coronary flow reserve.
FAU - Shinomiya, H
AU  - Shinomiya H
AD  - Division of Cardiology, Zentsuji National Hospital, Kagawa.
FAU - Fukuda, N
AU  - Fukuda N
FAU - Takeichi, N
AU  - Takeichi N
FAU - Soeki, T
AU  - Soeki T
FAU - Shinohara, H
AU  - Shinohara H
FAU - Yui, Y
AU  - Yui Y
FAU - Tamura, Y
AU  - Tamura Y
FAU - Fukada, Y
AU  - Fukada Y
FAU - Nakamura, M
AU  - Nakamura M
FAU - Miyatake, K
AU  - Miyatake K
FAU - Yutani, C
AU  - Yutani C
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Fatty Acids)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Iodobenzenes)
RN  - 0J7USQ749M (iodofiltic acid)
SB  - IM
MH  - Adult
MH  - Coronary Circulation
MH  - DNA, Mitochondrial/genetics
MH  - Echocardiography/*methods
MH  - Fatty Acids
MH  - Heart/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Iodine Radioisotopes
MH  - Iodobenzenes
MH  - MELAS Syndrome/*diagnostic imaging/physiopathology
MH  - Male
MH  - Mitochondrial Myopathies/*diagnostic imaging/genetics/physiopathology
MH  - Point Mutation
MH  - Radionuclide Imaging
EDAT- 1998/03/26 00:00
MHDA- 1998/03/26 00:01
CRDT- 1998/03/26 00:00
PHST- 1998/03/26 00:00 [pubmed]
PHST- 1998/03/26 00:01 [medline]
PHST- 1998/03/26 00:00 [entrez]
PST - ppublish
SO  - J Cardiol. 1998 Feb;31(2):109-14.