PMID- 9513844
OWN - NLM
STAT- MEDLINE
DCOM- 19980514
LR  - 20190515
IS  - 1058-0468 (Print)
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Linking)
VI  - 15
IP  - 2
DP  - 1998 Feb
TI  - Zona pellucida thickness variation and occurrence of visible mononucleated 
      blastomers in preembryos are associated with a high pregnancy rate in IVF 
      treatment.
PG  - 70-5
AB  - PURPOSE: The ability of six morphological criteria (embryo development rate, 
      fragmentation, regularity of blastomere shape, equality of blastomere size, zona 
      pellucida thickness variation [ZPTV], and visible mononucleated blastomeres 
      [VMBs]) to predict pregnancy in IVF treatment cycles was evaluated. METHODS: In 
      order to select a homogeneous study group, 85 consecutive nulliparous couples 
      with single tubal infertility undergoing their first IVF treatment and receiving 
      three preembryos at embryo replacement 2 days after ovum pickup were included. 
      RESULTS: A total of 255 preembryos was replaced two days after ovum pickup and 
      resulted in 34 clinical pregnancies (40%). By logistic regression analysis, ZPTV 
      and VMBs showed highly significant and strong predictive values, whereas none of 
      the other parameters was a significant predictor of pregnancy. In the treatments 
      in which all replaced preembryos had a ZPTV of less than 15%, the pregnancy rate 
      was extremely low (1/22). If the maximum ZPTV of any of the replaced preembryos 
      was in the interval between 15 and 20%, the pregnancy rate was 24.1% (7129). In 
      the treatments in which at least one preembryo had a ZPTV of more than 20%, the 
      pregnancy rate was 76.5% (26/34). When VMBs were added to the results of the ZPTV 
      analysis, the pregnancy rate was as high as 92.3% (24/26). CONCLUSIONS: ZPTV and 
      VMBs seem to be strong predictors of pregnancy in IVF treatment and thus 
      important indicators of good embryo quality.
FAU - Palmstierna, M
AU  - Palmstierna M
AD  - Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden.
FAU - Murkes, D
AU  - Murkes D
FAU - Csemiczky, G
AU  - Csemiczky G
FAU - Andersson, O
AU  - Andersson O
FAU - Wramsby, H
AU  - Wramsby H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - Adult
MH  - Blastomeres/*physiology/ultrastructure
MH  - *Embryo Transfer
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Microscopy, Phase-Contrast
MH  - Ovarian Follicle/diagnostic imaging/physiology
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - *Pregnancy Rate
MH  - Quality Control
MH  - Treatment Outcome
MH  - Ultrasonography
MH  - Videotape Recording
MH  - Zona Pellucida/*physiology/ultrastructure
PMC - PMC3455425
EDAT- 1998/03/26 00:00
MHDA- 1998/03/26 00:01
PMCR- 1999/01/01
CRDT- 1998/03/26 00:00
PHST- 1998/03/26 00:00 [pubmed]
PHST- 1998/03/26 00:01 [medline]
PHST- 1998/03/26 00:00 [entrez]
PHST- 1999/01/01 00:00 [pmc-release]
AID - BF02766828 [pii]
AID - 10.1007/BF02766828 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 1998 Feb;15(2):70-5. doi: 10.1007/BF02766828.