PMID- 9513919
OWN - NLM
STAT- MEDLINE
DCOM- 19980505
LR  - 20190909
IS  - 0388-1350 (Print)
IS  - 0388-1350 (Linking)
VI  - 23
IP  - 1
DP  - 1998 Feb
TI  - Pharmacokinetics and neurotoxicity of dipterex in hens. A comparative study of 
      administration methods.
PG  - 25-33
AB  - We compared the tissue concentration of dipterex and the inhibition of the 
      neuropathy target esterase (NTE) activity among groups of hens (n = 8 each) which 
      were intravenously (i.v.), subcutaneously (s.c.) or orally (p.o.) administered 
      the insecticide dipterex. The tissue concentrations of dipterex in the s.c. group 
      were higher than those in the i.v. and p.o. groups. When dosed subcutaneously, 
      the tissue concentration of dipterex was high in the brain, spinal cord and 
      muscle at 3 hr after dosing and then concentrated in the spinal cord and muscle 
      for the subsequent 3 hr. When dosed intravenously or orally, dipterex was evenly 
      dispersed in various tissues. All hens treated with dipterex showed acute 
      neurotoxic signs within 15 min after dosing. The hens dosed intravenously 
      recovered from this acute poisoning within 3 hr, and the hens dosed orally 
      recovered within 6 hr, while the hens dosed subcutaneously recovered within 24 hr 
      after dosing. One hen in the s.c. group exhibited acute neurological sequelae 
      following the acute poisoning. In addition, the loss of body weight was the 
      largest in the s.c. group (157 +/- 49 g), moderate in the i.v. group (133 +/- 91 
      g), small in the p.o. group (96 +/- 54 g) and the smallest in the PMSF 
      (phenylmethanesulfonyl fluoride, which was dosed to promote delayed neuropathy) 
      group (80 +/- 49 g). In the untreated hens, the activity of NTE in both the 
      cerebrum and cerebellum was higher than that in the midbrain (p < 0.01). There 
      was no difference in NTE activity between the cerebrum and cerebellum. In both 
      the cerebrum and midbrain, the inhibition of NTE activity in the p.o. group was 
      less than that in the i.v. and s.c. groups, and no difference was found between 
      the i.v. and s.c. groups. In the cerebellum, the inhibition of NTE activity in 
      the s.c. group was larger than that in the i.v. and p.o. groups. These results 
      indicate that the s.c. dosing of dipterex results in a stronger neurotoxicity 
      compared to i.v. and p.o. dosing. However, it was difficult to induce the 
      clinical signs of delayed neuropathy with any administration of dipterex in hens, 
      even when the promotion of delayed neurotoxicity of dipterex was attempted with 
      PMSF or double doses of dipterex itself.
FAU - Xie, X
AU  - Xie X
AD  - Department of Public Health, School of Medicine, Mie University, Tsu, Japan.
FAU - Piao, F Y
AU  - Piao FY
FAU - Tian, Y
AU  - Tian Y
FAU - Yamauchi, T
AU  - Yamauchi T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Insecticides)
RN  - 57KD15003I (Phenylmethylsulfonyl Fluoride)
RN  - DBF2DG4G2K (Trichlorfon)
RN  - EC 3.1.- (Esterases)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain/metabolism
MH  - Chickens
MH  - Cholinesterase Inhibitors/administration & dosage/*pharmacokinetics/*toxicity
MH  - Esterases/metabolism
MH  - Female
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Insecticides/administration & dosage/*pharmacokinetics/*toxicity
MH  - Muscles/metabolism
MH  - Peripheral Nervous System Diseases/chemically induced
MH  - Phenylmethylsulfonyl Fluoride/pharmacology
MH  - Spinal Cord/metabolism
MH  - Trichlorfon/administration & dosage/*pharmacokinetics/*toxicity
EDAT- 1998/03/26 00:00
MHDA- 1998/03/26 00:01
CRDT- 1998/03/26 00:00
PHST- 1998/03/26 00:00 [pubmed]
PHST- 1998/03/26 00:01 [medline]
PHST- 1998/03/26 00:00 [entrez]
AID - 10.2131/jts.23.25 [doi]
PST - ppublish
SO  - J Toxicol Sci. 1998 Feb;23(1):25-33. doi: 10.2131/jts.23.25.