PMID- 9515585
OWN - NLM
STAT- MEDLINE
DCOM- 19980506
LR  - 20190831
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 28
IP  - 2
DP  - 1998 Feb
TI  - Association study of asthma and atopy traits and chromosome 5q cytokine cluster 
      markers.
PG  - 141-50
AB  - BACKGROUND: Linkage studies have provided evidence for the presence of gene(s) in 
      the 5q cytokine cluster region which control total serum immunoglobulin E (IgE) 
      concentration, and bronchial hyperreactivity (BHR). However, the identification 
      of the gene(s) involved has been confounded by the lack of power of the published 
      linkage studies and the presence of multiple candidate genes mapped to the 
      region. OBJECTIVE: To define the important loci on 5q31-33 which are implicated 
      in the control of total serum IgE and BHR through a case/control study of 
      association. METHODS: We performed an association study between 11 polymorphic 
      markers (spanning the region 5q31.1-33.1) and total serum IgE and BHR traits. A 
      case/control sample of 181 individuals was drawn from a larger set of 2415 
      adults, sampled at random from a district in Nottingham, UK. Half of the subjects 
      in this case/control sample were hyperreactive to methacholine and asthmatic 
      (cases), while the other half were non-reactive and non-asthmatic (controls). 
      Association analysis was performed using the non-parametric chi-squared and 
      Mann-Whitney U-tests. RESULTS: We observed no evidence of strong allelic 
      association between any of the above markers and the studied traits. Markers 
      D5S404, interferon regulatory factor 1 (IRF-1) and D5S210 showed evidence of 
      borderline association with BHR (P = 0.04, 0.03 and 0.04 respectively), and 
      D5S404 showed borderline significance with IgE levels (P = 0.029). CONCLUSIONS: 
      This study presents evidence against the presence of a strong association between 
      markers mapped to 5q31-33 and either BHR or total serum IgE. The significance of 
      the weaker associations observed with markers D4S404, IRF-1 and D5S210 is not 
      clear. Whether this represents a type I error secondary to multiple hypothesis 
      testing or a true association is uncertain.
FAU - Mansur, A H
AU  - Mansur AH
AD  - Molecular Medicine Unit, St James's University Hospital, Leeds, UK.
FAU - Bishop, D T
AU  - Bishop DT
FAU - Markham, A F
AU  - Markham AF
FAU - Britton, J
AU  - Britton J
FAU - Morrison, J F
AU  - Morrison JF
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Genetic Markers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asthma/*genetics
MH  - Bronchial Hyperreactivity/genetics
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - DNA/blood/genetics
MH  - Female
MH  - Genetic Markers/*genetics
MH  - Genotype
MH  - Humans
MH  - Hypersensitivity, Immediate/*genetics
MH  - Immunoglobulin E/blood/genetics
MH  - Male
MH  - Microsatellite Repeats/genetics
MH  - Middle Aged
EDAT- 1998/03/27 00:00
MHDA- 1998/03/27 00:01
CRDT- 1998/03/27 00:00
PHST- 1998/03/27 00:00 [pubmed]
PHST- 1998/03/27 00:01 [medline]
PHST- 1998/03/27 00:00 [entrez]
AID - 10.1046/j.1365-2222.1998.00229.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 1998 Feb;28(2):141-50. doi: 10.1046/j.1365-2222.1998.00229.x.