PMID- 9517775
OWN - NLM
STAT- MEDLINE
DCOM- 19980506
LR  - 20151119
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 25
IP  - 3
DP  - 1998 Mar
TI  - Synovial fluid cartilage metabolism marker concentrations in osteonecrosis of the 
      femoral head compared with osteoarthrosis of the hip.
PG  - 527-31
AB  - OBJECTIVE: Biochemical aspects of the etiology of articular cartilage 
      degeneration in osteonecrosis of the femoral head have not been investigated 
      extensively. We analyzed biochemical conditions in the hip joint cavity, 
      regarding articular cartilage turnover in osteonecrosis of the femoral head 
      (ONFH). METHODS: Cartilage metabolism markers in synovial fluid were measured. 
      Synovial fluid (SF) samples were collected from 19 ONFH cases and 17 control hips 
      with osteoarthrosis (OA). Concentrations of carboxy-terminal type II procollagen 
      peptide (pCOL-II-C), matrix metalloproteinase-3 (MMP-3), and tissue inhibitor of 
      metalloproteinase-1 (TIMP-1) were measured. In addition, concentrations of 
      unsaturated disaccharides of hyaluronic acid (delta di-HA), chondroitin 4-sulfate 
      (delta di-4S), and chondroitin 6-sulfate (delta di-6S) in SF were measured by 
      high performance liquid chromatography. RESULTS: The mean SF concentration of 
      pCOL-II-C was higher on ONFH than in OA. The mean SF MMP-3 level was higher in 
      ONFH than in OA, while the mean SF TIMP-1 level was the same in the 2 groups. The 
      SF concentration of delta di-HA and the delta di-6S/delta di-4S ratio were higher 
      in ONFH than in OA. CONCLUSION: Higher concentrations of cartilage metabolism 
      markers in ONFH compared with OA SF suggest elevated cartilage turnover in the 
      former disease.
FAU - Iwase, T
AU  - Iwase T
AD  - Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan.
FAU - Hasegawa, Y
AU  - Hasegawa Y
FAU - Ishiguro, N
AU  - Ishiguro N
FAU - Ito, T
AU  - Ito T
FAU - Iwasada, S
AU  - Iwasada S
FAU - Kitamura, S
AU  - Kitamura S
FAU - Iwata, H
AU  - Iwata H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Biomarkers)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 9007-28-7 (Chondroitin Sulfates)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Cartilage/*metabolism
MH  - Chondroitin Sulfates/metabolism
MH  - Collagen/metabolism
MH  - Femur Head Necrosis/enzymology/*metabolism
MH  - Humans
MH  - Hyaluronic Acid/metabolism
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Middle Aged
MH  - Osteoarthritis, Hip/enzymology/*metabolism
MH  - Synovial Fluid/*metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/metabolism
EDAT- 1998/03/28 00:00
MHDA- 1998/03/28 00:01
CRDT- 1998/03/28 00:00
PHST- 1998/03/28 00:00 [pubmed]
PHST- 1998/03/28 00:01 [medline]
PHST- 1998/03/28 00:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 1998 Mar;25(3):527-31.