PMID- 9518613
OWN - NLM
STAT- MEDLINE
DCOM- 19980710
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 787
IP  - 2
DP  - 1998 Mar 23
TI  - Experimentally induced muscle pain induces hypoalgesia in heterotopic deep 
      tissues, but not in homotopic deep tissues.
PG  - 203-10
AB  - The ability of muscle pain to generate somatosensory sensibility changes is 
      controversial. Thus, in the present study, tonic infusion of hypertonic saline 
      (5%, 7.1 ml administered over 15 min) into the tibialis anterior (TA) muscle was 
      used as an experimental model to induce local and referred pain. The sensibility 
      to high-intensity pressure stimuli applied to the local pain area, referred pain 
      area and an arm was assessed in 14 healthy volunteers. Infusion of isotonic 
      (0.9%) saline into the other leg served as control. The subject continuously 
      scored the pain intensity on an electronic visual analogue scale (VAS). Pressure 
      pain threshold (PPT) was determined on the TA muscle (2 cm and 10 cm from the 
      infusion site), at the frontal aspect of the ankle (area of referred pain) and on 
      the arm. To minimise the skin component of the PPT, the skin covering the 
      assessment sites was anaesthetised with an anaesthetic creme. The PPTs were 
      obtained before and after cutaneous analgesia, 1 min and 10 min after infusion 
      start and 10 min after the pain had disappeared. Infusion of hypertonic saline 
      caused significantly (P<0. 05) higher VAS scores than infusion of isotonic 
      saline. A significant (P<0.04) increase of the PPT (i.e., decreased sensibility) 
      was found at the ankle and on the arm during muscle pain compared to the control 
      condition. No significant differences in PPTs on the TA muscle were found during 
      saline-induced muscle pain compared to the infusion of isotonic saline. The 
      decrease in deep sensibility at the heterotopic sites (referred pain area and 
      arm), but not at homotopic sites (TA muscle), probably reflected the phenomenon 
      of diffuse noxious inhibitory control (DNIC). The inhibitory mechanism during 
      muscle pain was shown to be effective for the deep tissue sensibility in healthy 
      subjects. Thus, a pathologically disturbed inhibitory mechanism may result in 
      widespread deep hyperalgesia in muscle pain patients.
CI  - Copyright 1998 Elsevier Science B.V.
FAU - Graven-Nielsen, T
AU  - Graven-Nielsen T
AD  - Center for Sensory-Motor Interaction, Laboratory for Experimental Pain Research, 
      Aalborg University, Aalborg, Denmark. tgn@miba.auc.uk
FAU - Babenko, V
AU  - Babenko V
FAU - Svensson, P
AU  - Svensson P
FAU - Arendt-Nielsen, L
AU  - Arendt-Nielsen L
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Saline Solution, Hypertonic)
SB  - IM
MH  - Adult
MH  - Ankle/physiology
MH  - Arm/physiology
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*physiopathology
MH  - Pain/*physiopathology/*psychology
MH  - Pain Measurement
MH  - Pain Threshold/physiology
MH  - Saline Solution, Hypertonic
EDAT- 1998/05/21 00:00
MHDA- 1998/05/21 00:01
CRDT- 1998/05/21 00:00
PHST- 1998/05/21 00:00 [pubmed]
PHST- 1998/05/21 00:01 [medline]
PHST- 1998/05/21 00:00 [entrez]
AID - S0006-8993(97)01480-7 [pii]
AID - 10.1016/s0006-8993(97)01480-7 [doi]
PST - ppublish
SO  - Brain Res. 1998 Mar 23;787(2):203-10. doi: 10.1016/s0006-8993(97)01480-7.