PMID- 9518672
OWN - NLM
STAT- MEDLINE
DCOM- 19980710
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 787
IP  - 2
DP  - 1998 Mar 23
TI  - Effect of adrenalectomy on cocaine facilitation of medial prefrontal cortex 
      self-stimulation.
PG  - 321-7
AB  - Adrenalectomy (ADX) is known to block the acquisition of intravenous cocaine 
      self-administration. A previous study therefore examined whether ADX decreases 
      sensitivity of the 'brain reward system' in general, or its response to cocaine 
      in particular, by measuring thresholds for intracranial self-stimulation with and 
      without concurrent cocaine administration. ADX had no effect on thresholds for 
      lateral hypothalamic self-stimulation (LHSS) and did not alter the cocaine 
      dose-response curve for lowering the LHSS threshold. This result suggested that 
      ADX does not affect sensitivity of the brain reward system. However, medial 
      prefrontal cortex (MPFC) appears to be an important site in the mediation of 
      cocaine reinforcing effects, and MPFC self-stimulation (MPFCSS) is mediated by a 
      neural substrate that is largely independent of that which mediates LHSS. The 
      present study therefore assessed whether ADX diminishes cocaine facilitation of 
      MPFCSS. It was found that the threshold-lowering effect of cocaine (5.0, 10.0 and 
      20.0 mg/kg, i.p. ) did not differ between ADX rats maintained on 0.7% saline, ADX 
      rats maintained on corticosterone (50 microg/ml) in 0.7% saline, and 
      sham-operated controls. However, there was a trend toward desensitization of 
      MPFCSS, itself, following ADX in the group that did not receive corticosterone 
      supplementation. Based on this observation, and the similar responses of MPFCSS 
      and cocaine self-administration to noncontingent priming stimulation, stress, and 
      NMDA receptor antagonism, it is speculated that acquisition of MPFCSS and cocaine 
      self-administration may be dependent upon a common sensitization process that is 
      regulated by corticosterone.
CI  - Copyright 1998 Elsevier Science B.V.
FAU - Carr, K D
AU  - Carr KD
AD  - Millhauser Laboratories, Department of Psychiatry, New York University Medical 
      Center, 550 First Avenue, New York, NY 10016, USA.
FAU - Abrahamsen, G C
AU  - Abrahamsen GC
LA  - eng
GR  - DA-00292/DA/NIDA NIH HHS/United States
GR  - DA-03956/DA/NIDA NIH HHS/United States
GR  - T32 DA-07254/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Narcotics)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - *Adrenalectomy
MH  - Animals
MH  - Cocaine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hypothalamic Area, Lateral/physiology
MH  - Male
MH  - Narcotics/*pharmacology
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Stimulation/*drug effects
EDAT- 1998/05/21 00:00
MHDA- 1998/05/21 00:01
CRDT- 1998/05/21 00:00
PHST- 1998/05/21 00:00 [pubmed]
PHST- 1998/05/21 00:01 [medline]
PHST- 1998/05/21 00:00 [entrez]
AID - S0006-8993(97)01487-X [pii]
AID - 10.1016/s0006-8993(97)01487-x [doi]
PST - ppublish
SO  - Brain Res. 1998 Mar 23;787(2):321-7. doi: 10.1016/s0006-8993(97)01487-x.