PMID- 9520188
OWN - NLM
STAT- MEDLINE
DCOM- 19980423
LR  - 20190914
IS  - 0277-3740 (Print)
IS  - 0277-3740 (Linking)
VI  - 17
IP  - 2
DP  - 1998 Mar
TI  - Role of presensitization and donor-recipient crossmatching in corneal graft 
      outcome.
PG  - 141-5
AB  - PURPOSE: A positive donor-recipient crossmatch (CM) due to preexisting recipient 
      lymphocytotoxic antibodies is known to be an important factor in allograft 
      failure in the majority of organ transplantations. However, the effect of 
      positive CM on corneal graft outcome is less known. METHOD: Between 1982 and 
      1994, CM was performed by the microlymphocytotoxicity method using donor 
      lymphocytes and recipient pretransplant serum in 759 consecutive corneal 
      transplantations (maximal follow-up, 36 months). Patients were evaluated 
      regarding the type of allospecificity of antibodies involved and their role on 
      corneal graft outcome (rejection and failure). RESULTS: A positive CM was found 
      in 61 patients (8%) and a negative CM in 698 patients (92%). The positive and 
      negative CM groups had similar graft rejection rates at 36 months. Patients with 
      a positive CM due to antibodies directed against donor human leukocyte antigen 
      (HLA) (as defined on the basis of private and public or CREG HLA allele 
      specificities) did not have an increased risk of rejection. However, patients 
      with positive CM and presensitization (previous graft or rejection history) had a 
      statistically significant increase in risk of corneal endothelial rejection. 
      CONCLUSION: This study shows that donor-recipient CM could be a useful procedure 
      for the selection of recipients for corneal transplantation in patients 
      presensitized by anterior graft or previous corneal rejection.
FAU - Des Marchais, B
AU  - Des Marchais B
AD  - Centre de Recherche en Rhumatologie-Immunologie, Centre Hospitalier Universitaire 
      de Quebec, Ste-Foy, Canada.
FAU - Bazin, R
AU  - Bazin R
FAU - Boisjoly, H M
AU  - Boisjoly HM
FAU - Laughrea, P A
AU  - Laughrea PA
FAU - Dube, I
AU  - Dube I
FAU - Lille, S
AU  - Lille S
FAU - Roy, R
AU  - Roy R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cornea/*immunology
MH  - Corneal Transplantation/*immunology
MH  - Cytotoxicity Tests, Immunologic
MH  - Graft Rejection/immunology
MH  - Graft Survival/immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Immunization
MH  - Isoantibodies/analysis
MH  - *Tissue Donors
MH  - Treatment Outcome
EDAT- 1998/03/31 00:00
MHDA- 1998/03/31 00:01
CRDT- 1998/03/31 00:00
PHST- 1998/03/31 00:00 [pubmed]
PHST- 1998/03/31 00:01 [medline]
PHST- 1998/03/31 00:00 [entrez]
AID - 00003226-199803000-00004 [pii]
AID - 10.1097/00003226-199803000-00004 [doi]
PST - ppublish
SO  - Cornea. 1998 Mar;17(2):141-5. doi: 10.1097/00003226-199803000-00004.