PMID- 9522421
OWN - NLM
STAT- MEDLINE
DCOM- 19980428
LR  - 20061115
IS  - 0036-7672 (Print)
IS  - 0036-7672 (Linking)
VI  - 128
IP  - 5
DP  - 1998 Jan 31
TI  - [Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA)].
PG  - 150-61
AB  - Long-term health effects of moderate ambient air pollution are rarely 
      investigated. In Switzerland, no large-scale study has addressed this issue so 
      far. Important results of the Swiss Study on Air Pollution and Lung Disease in 
      Adults (SAPALDIA) are presented. During the period 1991-1993, SAPALDIA 
      investigated a random population sample (18-60 years) in eight Swiss areas with 
      different environmental characteristics (Aarau, Basel, Davos, Geneva, Lugano, 
      Montana, Payerne, Wald). In total, 9651 adults (60%) participated in the 
      cross-sectional investigation (part 1, 1991), consisting of the following 
      standardized procedures: questionnaire (interview), forced expiratory lung 
      function test, bronchial challenge with methacholine, atopy assessment 
      (Phadiatop, unspecific total IgE), allergy skin tests, and endexpiratory 
      CO-measurements. Subjects with a history of respiratory symptoms, increased 
      bronchial reactivity, reduced lung function (FEV1/FVC < 80% predicted) and 150 
      healthy never-smokers were included in the subsequent diary study (part 2; n = 
      3281, 1992/93). Peak flow (morning and evening), symptoms, medication, personal 
      activity and visits to the doctor were monitored. Across regions, annual mean 
      values ranged from 9 to 52 mg/m3 (NO2) and 10 to 33 mg/m3 (PM10) respectively. 
      Air pollution had effects on prevalence of dyspnea (+41% per 10 mg/m3 increment 
      of the annual mean PM10, 95% CI 20-65%), on symptoms of chronic bronchitis (+31%, 
      10-55%), on FVC (-3.1%; -3.7 to -2.6%), and FEV1 (-1.1%; -1.7% to -0.5%), on the 
      incidence of respiratory symptoms and the length of symptomfree intervals (11% 
      change per 10 mg/m3 PM10), but not on the prevalence of asthma. Environmental 
      tobacco smoke (ETS) showed impact on wheezing (OR 1.94; 1.39-2.70), asthma (1.39; 
      1.04-1.86), bronchitis (1.60; 1.24-2.08) and chronic bronchitis (1.50; 
      1.11-2.02). Health effects of moderate air pollution were confirmed in 
      Switzerland. Although for the individual the relative risks are small, the public 
      health impact may be considerable. An ongoing follow-up will investigate the 
      mortality profile of the SAPALDIA cohort.
FAU - Leuenberger, P
AU  - Leuenberger P
AD  - Division de pneumologie, CHUV, Lausanne.
FAU - Kunzli, N
AU  - Kunzli N
FAU - Ackermann-Liebrich, U
AU  - Ackermann-Liebrich U
FAU - Schindler, C
AU  - Schindler C
FAU - Bolognini, G
AU  - Bolognini G
FAU - Bongard, J P
AU  - Bongard JP
FAU - Brandli, O
AU  - Brandli O
FAU - Defila, C
AU  - Defila C
FAU - Domenighetti, G
AU  - Domenighetti G
FAU - Karrer, W
AU  - Karrer W
FAU - Keller, R
AU  - Keller R
FAU - Medici, T
AU  - Medici T
FAU - Monn, C
AU  - Monn C
FAU - Perruchoud, A P
AU  - Perruchoud AP
FAU - Schoni, M
AU  - Schoni M
FAU - Tschopp, J M
AU  - Tschopp JM
FAU - Villiger, B
AU  - Villiger B
FAU - Wuthrich, B
AU  - Wuthrich B
FAU - Zellweger, J P
AU  - Zellweger JP
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Etude suisse sur la pollution de l'air et les maladies respiratoires chez 
      l'adulte (SAPALDIA). Swiss Study on Air Pollution and Lung Diseases in Adults.
PL  - Switzerland
TA  - Schweiz Med Wochenschr
JT  - Schweizerische medizinische Wochenschrift
JID - 0404401
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Air Pollution/*adverse effects/statistics & numerical data
MH  - Bronchial Provocation Tests
MH  - Cross-Sectional Studies
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Lung Diseases/epidemiology/*etiology
MH  - Lung Diseases, Obstructive/epidemiology/etiology
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance
MH  - Risk
MH  - Switzerland/epidemiology
EDAT- 1998/04/02 00:00
MHDA- 1998/04/02 00:01
CRDT- 1998/04/02 00:00
PHST- 1998/04/02 00:00 [pubmed]
PHST- 1998/04/02 00:01 [medline]
PHST- 1998/04/02 00:00 [entrez]
PST - ppublish
SO  - Schweiz Med Wochenschr. 1998 Jan 31;128(5):150-61.