PMID- 9524765
OWN - NLM
STAT- MEDLINE
DCOM- 19980518
LR  - 20190905
IS  - 0300-5208 (Print)
IS  - 0300-5208 (Linking)
VI  - 212
DP  - 1997
TI  - Domain structure of hepatocyte growth factor/scatter factor (HGF/SF).
PG  - 84-93; discussion 93-104
AB  - The modular structure of hepatocyte growth factor/scatter factor (HGF/SF) has 
      facilitated structure-function analysis. Domain deletion experiments have 
      established that the N-domain, kringle 1 and kringle 2 are essential for HGF/SF 
      activity on target cells and that, conversely, truncated variants containing the 
      N-domain and kringle 1 (NK1) or kringles 1 and 2 (NK2) exhibit partial agonistic 
      or antagonistic activity depending on target cells and the presence of full 
      length HGF/SF. The 3D structures of the six domains of HGF/SF have been modelled 
      on the structure of homologues, offering interesting insights into putative 
      mechanisms of domain interactions, receptor binding and activation. The 
      predictions offered by such models are currently assessed by protein engineering 
      techniques and will ultimately be measured against experimental structures.
FAU - Gherardi, E
AU  - Gherardi E
AD  - Cambridge University Medical School, MRC Centre, UK.
FAU - Hartmann, G
AU  - Hartmann G
FAU - Hepple, J
AU  - Hepple J
FAU - Chirgadze, D
AU  - Chirgadze D
FAU - Srinivasan, N
AU  - Srinivasan N
FAU - Blundell, T
AU  - Blundell T
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Ciba Found Symp
JT  - Ciba Foundation symposium
JID - 0356636
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Gene Deletion
MH  - Hepatocyte Growth Factor/*chemistry/metabolism/physiology
MH  - Kringles
MH  - Models, Molecular
MH  - Mutagenesis, Site-Directed
MH  - *Protein Structure, Tertiary
MH  - Proto-Oncogene Proteins c-met/*metabolism
MH  - Structure-Activity Relationship
RF  - 28
EDAT- 1997/01/01 00:00
MHDA- 1998/04/03 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/04/03 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1002/9780470515457.ch6 [doi]
PST - ppublish
SO  - Ciba Found Symp. 1997;212:84-93; discussion 93-104. doi: 
      10.1002/9780470515457.ch6.