PMID- 9524770
OWN - NLM
STAT- MEDLINE
DCOM- 19980518
LR  - 20190905
IS  - 0300-5208 (Print)
IS  - 0300-5208 (Linking)
VI  - 212
DP  - 1997
TI  - The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian 
      development.
PG  - 169-77; discussion 177-82
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) can induce 
      epithelial-mesenchymal conversion of epithelial cells in culture, with the 
      dissociated cells becoming highly motile. The signal given by HGF/SF is mediated 
      by its specific receptor, the c-Met tyrosine kinase. Targeted mutations in the 
      mouse have demonstrated that HGF/SF and c-Met take over functions in development 
      of the placenta, liver and skeletal muscle. During development of skeletal 
      muscle, the receptor and its ligand control migration of myogenic precursor cells 
      in the embryo. These myogenic precursors undergo an epithelial-mesenchymal 
      conversion and detach from the dermomyotome of the somite. They then migrate to 
      different sites in the embryo where they terminally differentiate to form 
      skeletal muscle. Mutations in the HGF/SF or c-met genes abolish emigration of 
      myogenic precursor cells. As a consequence, skeletal muscle groups that derive 
      from migrating cells do not form. Ectopic application of HGF/SF in the chick 
      embryo induces epithelial-mesenchymal conversion and emigration of dermomyotomal 
      cells. Moreover, the expression patterns of HGF/SF and c-Met in the mouse embryo 
      are in accordance with a function of HGF/SF in the induction of 
      epithelial-mesenchymal conversion and the generation of migrating myogenic 
      precursor cells in vivo. The pattern suggests additional roles during the 
      migratory process, which will be discussed.
FAU - Birchmeier, C
AU  - Birchmeier C
AD  - Max-Delbruck-Center for Molecular Medicine, Department of Medical Genetics, 
      Berlin, Germany.
FAU - Bladt, F
AU  - Bladt F
FAU - Yamaai, T
AU  - Yamaai T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Ciba Found Symp
JT  - Ciba Foundation symposium
JID - 0356636
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Embryonic and Fetal Development/physiology
MH  - Epithelial Cells/physiology
MH  - Hepatocyte Growth Factor/*physiology
MH  - Humans
MH  - Mammals/*embryology
MH  - Muscle, Skeletal/embryology
MH  - Phenotype
MH  - Proto-Oncogene Proteins c-met/*physiology
EDAT- 1997/01/01 00:00
MHDA- 1998/04/03 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/04/03 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1002/9780470515457.ch11 [doi]
PST - ppublish
SO  - Ciba Found Symp. 1997;212:169-77; discussion 177-82. doi: 
      10.1002/9780470515457.ch11.