PMID- 9524773
OWN - NLM
STAT- MEDLINE
DCOM- 19980518
LR  - 20211203
IS  - 0300-5208 (Print)
IS  - 0300-5208 (Linking)
VI  - 212
DP  - 1997
TI  - HGF/SF in angiogenesis.
PG  - 215-26; discussion 227-9
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a mesenchyme-derived cytokine 
      that stimulates motility and invasiveness of epithelial and cancer cells. These 
      responses are transduced through the c-met proto-oncogene product, a 
      transmembrane tyrosine kinase that functions as the HGF/SF receptor. We have 
      shown that HGF/SF is a potent angiogenic molecule and that its angiogenic 
      activity is mediated primarily through direct actions on vascular endothelial 
      cells. These include stimulation of cell migration, proliferation, protease 
      production, invasion, and organization into capillary-like tubes. We further 
      showed that HGF/SF is overexpressed in invasive human cancers, including breast 
      cancer, relative to non-invasive cancers and benign conditions. In invasive 
      breast cancers, the content of HGF/SF is strongly correlated with that of von 
      Willebrand's factor, a marker of vascular endothelial cells. Furthermore, 
      transfection of breast cancer and glioma cell lines with HGF/SF cDNA greatly 
      enhanced the ability of these cells to grow as tumours in orthotopic sites in 
      syngeneic or immunocompromized host animals. The increased growth rate of the 
      HGF/SF-transfected cells was attributable, in part, to increased tumour 
      angiogenesis. These findings suggest that HGF/SF may function as a tumour 
      progression factor, in part by stimulating tumour cell invasiveness and in part 
      by stimulating angiogenesis.
FAU - Rosen, E M
AU  - Rosen EM
AD  - Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde 
      Park, NY 11040, USA.
FAU - Lamszus, K
AU  - Lamszus K
FAU - Laterra, J
AU  - Laterra J
FAU - Polverini, P J
AU  - Polverini PJ
FAU - Rubin, J S
AU  - Rubin JS
FAU - Goldberg, I D
AU  - Goldberg ID
LA  - eng
GR  - CA-64416/CA/NCI NIH HHS/United States
GR  - CA-64869/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - Ciba Found Symp
JT  - Ciba Foundation symposium
JID - 0356636
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Cell Division/physiology
MH  - Cell Movement/physiology
MH  - Endothelium, Vascular/cytology/physiology
MH  - Hepatocyte Growth Factor/*physiology
MH  - Humans
MH  - Neoplasms/*blood supply
MH  - Neoplasms, Experimental/*blood supply
MH  - *Neovascularization, Pathologic
MH  - *Neovascularization, Physiologic
MH  - Proto-Oncogene Mas
RF  - 61
EDAT- 1997/01/01 00:00
MHDA- 1998/04/03 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/04/03 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1002/9780470515457.ch14 [doi]
PST - ppublish
SO  - Ciba Found Symp. 1997;212:215-26; discussion 227-9. doi: 
      10.1002/9780470515457.ch14.