PMID- 9526029
OWN - NLM
STAT- MEDLINE
DCOM- 19980529
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 785
IP  - 1
DP  - 1998 Feb 23
TI  - Repeated exposure to methylenedioxymethamphetamine (MDMA) alters nucleus 
      accumbens neuronal responses to dopamine and serotonin.
PG  - 1-9
AB  - The purpose of this experiment was to investigate the effects of repeated 
      exposure to methylenedioxymethamphetamine (MDMA) on responses of neurons in the 
      nucleus accumbens of anesthetized rats to microiontophoretically-applied dopamine 
      and serotonin. In tests conducted 1-4 days or 9-15 days following the last 
      injection of MDMA (20 mg/kg, s.c., twice daily for 4 days), the inhibitory 
      effects of both dopamine and serotonin on glutamate-evoked firing of nucleus 
      accumbens cells were significantly attenuated compared to effects in control rats 
      that were pretreated with saline injections. The inhibitory effect of the D1 
      receptor agonist SKF38393 was also significantly attenuated in the 
      MDMA-pretreated rats. In contrast, the amount of inhibition of glutamate-evoked 
      firing produced by application of GABA did not significantly differ between the 
      MDMA-pretreated and the saline-pretreated rats. The neurotoxicity of the MDMA 
      treatment regimen was confirmed by demonstrating that 3H-paroxetine binding was 
      significantly decreased in the medial prefrontal cortex and the nucleus accumbens 
      of the MDMA-pretreated rats. The mechanisms that produce the attenuated 
      inhibitory responses to dopamine and serotonin following repeated injections of 
      MDMA are not known. However, the results of these experiments indicate that 
      repeated MDMA administration induces long-lasting changes in dopaminergic as well 
      as serotonergic neurotransmission in the nucleus accumbens.
CI  - Copyright 1998 Elsevier Science B.V.
FAU - Obradovic, T
AU  - Obradovic T
AD  - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, 
      Washington State University, Pullman, WA 99164, USA.
FAU - Imel, K M
AU  - Imel KM
FAU - White, S R
AU  - White SR
LA  - eng
GR  - DA08116/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Dopamine D1)
RN  - 333DO1RDJY (Serotonin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
MH  - Animals
MH  - Dopamine/*pharmacology
MH  - Drug Administration Schedule
MH  - Evoked Potentials/drug effects
MH  - Glutamic Acid/pharmacology
MH  - Injections, Subcutaneous
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Neurons/drug effects/*physiology
MH  - Nucleus Accumbens/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/agonists
MH  - Serotonin/*pharmacology
MH  - Time Factors
MH  - gamma-Aminobutyric Acid/pharmacology
EDAT- 1998/06/06 00:00
MHDA- 1998/06/06 00:01
CRDT- 1998/06/06 00:00
PHST- 1998/06/06 00:00 [pubmed]
PHST- 1998/06/06 00:01 [medline]
PHST- 1998/06/06 00:00 [entrez]
AID - S0006-8993(97)01337-1 [pii]
AID - 10.1016/s0006-8993(97)01337-1 [doi]
PST - ppublish
SO  - Brain Res. 1998 Feb 23;785(1):1-9. doi: 10.1016/s0006-8993(97)01337-1.