PMID- 9526948
OWN - NLM
STAT- MEDLINE
DCOM- 19980521
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 88
IP  - 3
DP  - 1997 Nov 1
TI  - Enhanced blood coagulation and enhanced fibrinolysis during hemodialysis with 
      prostacyclin.
PG  - 283-90
AB  - In the present study the effect of unfractionated heparin (UFH) (Liquemin, 
      750-1000 IU/h), low molecular weight heparin (LMWH) (Fragmin, 3000-7250 IU 
      bolus), and prostacyclin (Flolan, 5 ng/kg body weight/min) on the activation of 
      blood coagulation and fibrinolysis, induced by polysulfone membrane dialyzers 
      during hemodialysis, was compared. Plasma levels of thrombin-antithrombin III 
      complex (TAT), fibrin split product D-dimer, and plasmin-plasmin 
      inhibitor-complex (PPI) were measured in the arterial and venous line of the 
      dialyzer at the beginning and at 10, 60, 120, and 180 minutes of hemodialysis. 
      Five patients on chronic hemodialysis treatment were investigated in a cross over 
      study. Clinically all three anticoagulation regimen were sufficient for 
      hemodialysis treatment. Using UFH or LMWH TAT, PPI, and D-dimer levels were 
      similar in the venous and the arterial line of the dialyzer. However, during 
      prostacyclin treatment the levels of these activation markers were significantly 
      higher in the venous line. Based on these data the dialyzer membrane can be 
      considered as a site of activation of blood coagulation and of fibrinolysis 
      during anticoagulation with prostacyclin in hemodialysis.
FAU - Novacek, G
AU  - Novacek G
AD  - Department of Internal Medicine IV, Gastroenterology and Hepatology, University 
      of Vienna, Austria.
FAU - Kapiotis, S
AU  - Kapiotis S
FAU - Jilma, B
AU  - Jilma B
FAU - Quehenberger, P
AU  - Quehenberger P
FAU - Michitsch, A
AU  - Michitsch A
FAU - Traindl, O
AU  - Traindl O
FAU - Speiser, W
AU  - Speiser W
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antihypertensive Agents/*adverse effects
MH  - Epoprostenol/*adverse effects
MH  - Female
MH  - *Fibrinolysis
MH  - Humans
MH  - Hypertension/complications/therapy
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/*adverse effects
MH  - Renal Dialysis/*adverse effects
MH  - Renal Insufficiency/*blood/etiology/therapy
EDAT- 1998/04/04 00:00
MHDA- 1998/04/04 00:01
CRDT- 1998/04/04 00:00
PHST- 1998/04/04 00:00 [pubmed]
PHST- 1998/04/04 00:01 [medline]
PHST- 1998/04/04 00:00 [entrez]
AID - S0049-3848(97)00255-7 [pii]
AID - 10.1016/s0049-3848(97)00255-7 [doi]
PST - ppublish
SO  - Thromb Res. 1997 Nov 1;88(3):283-90. doi: 10.1016/s0049-3848(97)00255-7.