PMID- 9528906
OWN - NLM
STAT- MEDLINE
DCOM- 19980413
LR  - 20190512
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 111
IP  - 3
DP  - 1998 Mar
TI  - Correlation of plasma monocyte chemoattractant protein-1 (MCP-1) and monocyte 
      inflammatory protein-1alpha (MIP-1alpha) levels with disease activity and 
      clinical course of sarcoidosis.
PG  - 604-10
AB  - MCP-1 and MIP-1alpha exhibit chemotactic activity toward macrophages/monocytes 
      and induce the production of inflammatory cytokines affecting granuloma 
      formation. Up-regulated expression of MCP-1 and MIP-1alpha in the affected organ 
      of sarcoidosis has been shown; however, the relationship between their plasma 
      levels and the clinical course of this disease has not been determined. In the 
      present study we measured plasma MCP-1 and MIP-1alpha levels in 26 patients with 
      active sarcoidosis by ELISA in order to assess the state of MCP-1 and MIP-1alpha 
      in this disease. Most patients in this study (21/26) had clinical evidence of 
      extrathoracic disease in addition to pulmonary involvement. In addition, a high 
      proportion of patients (n = 15) showed spontaneous remission of disease, whereas 
      five patients showed no spontaneous remission and six patients were treated with 
      corticosteroids over the 2-year period of study. At the time of diagnosis, both 
      plasma MCP-1 and MIP-1alpha levels in patients with active sarcoidosis were 
      significantly higher than in the normal controls. The levels of these cytokines 
      in patients with extrathoracic disease were compatible with those in patients 
      without extrathoracic disease. A longitudinal evaluation of plasma MCP-1 and 
      MIP-1alpha levels showed that the changes in both cytokines were closely related 
      to the clinical course of sarcoidosis. These results suggest that plasma MCP-1 
      and MIP-1alpha may be useful parameters for monitoring the clinical course of 
      sarcoidosis. In addition, plasma MCP-1 and MIP-1alpha may reflect subclinical 
      evidence of extrathoracic sarcoidosis and may play a role in initiating monocyte 
      migration into the tissue.
FAU - Hashimoto, S
AU  - Hashimoto S
AD  - First Department of Internal Medicine, Nihon University School of Medicine, 
      Tokyo, Japan.
FAU - Nakayama, T
AU  - Nakayama T
FAU - Gon, Y
AU  - Gon Y
FAU - Hata, N
AU  - Hata N
FAU - Koura, T
AU  - Koura T
FAU - Maruoka, S
AU  - Maruoka S
FAU - Matsumoto, K
AU  - Matsumoto K
FAU - Hayashi, S
AU  - Hayashi S
FAU - Abe, Y
AU  - Abe Y
FAU - Horie, T
AU  - Horie T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Macrophage Inflammatory Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*blood
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Lung Diseases/*blood/pathology
MH  - Macrophage Inflammatory Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis/*blood/pathology
PMC - PMC1904889
EDAT- 1998/04/07 00:00
MHDA- 1998/04/07 00:01
PMCR- 1999/03/01
CRDT- 1998/04/07 00:00
PHST- 1998/04/07 00:00 [pubmed]
PHST- 1998/04/07 00:01 [medline]
PHST- 1998/04/07 00:00 [entrez]
PHST- 1999/03/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2249.1998.00519.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1998 Mar;111(3):604-10. doi: 10.1046/j.1365-2249.1998.00519.x.