PMID- 9530334
OWN - NLM
STAT- MEDLINE
DCOM- 19980408
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 102
IP  - 1
DP  - 1998 Apr 1
TI  - A new variant translocation of t(15;17) in a patient with acute promyelocytic 
      leukemia (M3): t(15;19;17)(q22;p13;q12).
PG  - 15-8
AB  - The reciprocal translocation (15;17) is specifically associated with acute 
      promyelocytic leukemia [APL; M3 subtype according to French-American-British 
      (FAB) classification]. A few patients with this disease have complex variant 
      translocations. We describe a patient with M3 carrying t(15;19;17)(q22;p13;q12), 
      which is a new type of variant translocation. The karyotypic interpretation was 
      confirmed by Southern blot analysis with the use of RAR alpha and by fluorescence 
      in situ hybridization (FISH) with the use of painting probes of chromosomes 15, 
      17, and 19 and a (15;17) translocation DNA probe. The results support the idea 
      that the key event in APL is the formation of fusion gene PML/RAR alpha on the 
      der(15).
FAU - Saitoh, K
AU  - Saitoh K
AD  - Third Department of Internal Medicine, Akita University School of Medicine, 
      Japan.
FAU - Miura, I
AU  - Miura I
FAU - Kobayashi, Y
AU  - Kobayashi Y
FAU - Kume, M
AU  - Kume M
FAU - Utsumi, S
AU  - Utsumi S
FAU - Takahashi, N
AU  - Takahashi N
FAU - Hatano, Y
AU  - Hatano Y
FAU - Nimura, T
AU  - Nimura T
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Takahashi, S
AU  - Takahashi S
FAU - Miura, A B
AU  - Miura AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Blotting, Southern
MH  - *Chromosomes, Human, Pair 15
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 19
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - *Translocation, Genetic
EDAT- 1998/04/08 00:00
MHDA- 1998/04/08 00:01
CRDT- 1998/04/08 00:00
PHST- 1998/04/08 00:00 [pubmed]
PHST- 1998/04/08 00:01 [medline]
PHST- 1998/04/08 00:00 [entrez]
AID - S0165460897002999 [pii]
AID - 10.1016/s0165-4608(97)00299-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Apr 1;102(1):15-8. doi: 
      10.1016/s0165-4608(97)00299-9.