PMID- 9531643
OWN - NLM
STAT- MEDLINE
DCOM- 19980520
LR  - 20061115
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 15
IP  - 2
DP  - 1998 Apr 10
TI  - [Molecular cytogenetic study on four human esophageal cancer cell lines].
PG  - 75-7
AB  - OBJECTIVE: To investigate the possible involvement of chromosome abnormalities in 
      pathogenesis of human esophageal cancer. METHODS: Four cell lines of human 
      esophageal cancer (EC) established in our laboratory were analysed using 
      interphase fluorescence in situ hybridization (FISH), chromosome painting 
      technique and comparative genomic hybridization (CGH). RESULTS: Chromosome gain 
      of 1,2,3,8,16, 17, and 20 was found in the four cell lines, and loss of 
      chromosome Y in cell line EC8712, EC8733 and EC8501 was noted. Other frequent 
      changes were partial deletion of 1p, translocation of 2q and amplification of 5p 
      in all 4 cell lines, and amplification of 8q and 13q in EC8733 and deletion of 
      17p in EC8712. CONCLUSION: The data suggest that nonrandom chromosome aberrations 
      may play an important role in the pathogenesis of human esophageal cancer.
FAU - Xiao, F
AU  - Xiao F
AD  - Nation Laboratory Molecular Oncology Cancer Institute, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100021 P. R. China.
FAU - Wang, X
AU  - Wang X
FAU - Wang, M
AU  - Wang M
FAU - Guan, X
AU  - Guan X
FAU - Wu, M
AU  - Wu M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adult
MH  - Cell Line
MH  - *Chromosome Aberrations
MH  - Esophageal Neoplasms/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Tumor Cells, Cultured
EDAT- 1998/05/23 00:00
MHDA- 1998/05/23 00:01
CRDT- 1998/05/23 00:00
PHST- 1998/05/23 00:00 [pubmed]
PHST- 1998/05/23 00:01 [medline]
PHST- 1998/05/23 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Apr 10;15(2):75-7.