PMID- 9531660
OWN - NLM
STAT- MEDLINE
DCOM- 19980608
LR  - 20191102
IS  - 1201-9712 (Print)
IS  - 1201-9712 (Linking)
VI  - 2
IP  - 3
DP  - 1998 Jan-Mar
TI  - Relationship of HLA-DQA1 alleles and humoral antibody following measles 
      vaccination.
PG  - 143-6
AB  - BACKGROUND: The human leukocyte antigen (HLA)-DQA1 locus is only moderately 
      polymorphic compared to other HLA class II loci; however, we hypothesized that 
      these polymorphisms could be important in determining the humoral antibody 
      response to measles vaccine virus. METHODS: The seroprevalence of measles 
      antibody was determined in 881 school children who had been immunized with MMR-II 
      at age approximately 15 months. All subjects resided in a geographic area with no 
      circulating measles virus. The IgG antibody levels were determined by a 
      measles-specific whole virus enzyme immunoassay (EIA) (BioWhittaker, 
      Walkersville, MD). Subjects who were nonresponders (IgG seronegative or 
      equivocal) (n = 46) and hyperresponders (upper 10th percentile of IgG levels of 
      all subjects) (n = 64) were HLA-DQA1 typed using polymerase chain reaction with 
      sequence-specific primers (PCR-SSP). The HLA-DQA1 allele frequencies, as well as 
      homozygosity rates, were compared between the nonresponders and hyperresponders. 
      RESULTS: The overall allele frequency distribution of alleles between the 
      nonresponders and hyperresponders was significantly different (P = 0.05), with 
      nonresponders having an excess of HLA-DQA1*05 alleles (P = 0.017) and 
      hyperresponders having an excess of HLA-DQA1*01 alleles (P = 0. 016). The 
      homozygosity rate among nonresponders was significantly higher than among 
      hyperresponders (23.9% vs. 9.4%, P = 0.037). CONCLUSION: HLA-DQA1 alleles have 
      important associations with the antibody response to measles vaccine. 
      Specifically, the carriage of the HLA-DQA1*05 alleles is associated with 
      nonresponse and that of HLA-DQA1*01 alleles with hyperresponse. In addition, 
      HLA-DQA1 homozygosity is significantly associated with poor antibody response to 
      measles vaccine.
FAU - Hayney, M S
AU  - Hayney MS
AD  - Mayo Vaccine Research Group, Clinical Pharmacology Unit, Mayo Clinic and 
      Foundation, Rochester, Minnesota 55905, USA.
FAU - Poland, G A
AU  - Poland GA
FAU - Jacobson, R M
AU  - Jacobson RM
FAU - Rabe, D
AU  - Rabe D
FAU - Schaid, D J
AU  - Schaid DJ
FAU - Jacobsen, S J
AU  - Jacobsen SJ
FAU - Lipsky, J J
AU  - Lipsky JJ
LA  - eng
GR  - AR 30582/AR/NIAMS NIH HHS/United States
GR  - N01-AI-45240/AI/NIAID NIH HHS/United States
GR  - R01-AI-33144/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Measles Vaccine)
SB  - IM
MH  - Adolescent
MH  - *Alleles
MH  - Antibodies, Viral/*biosynthesis/immunology
MH  - Antibody Formation/genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Homozygote
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin G/immunology
MH  - Infant
MH  - Male
MH  - Measles Vaccine/*immunology
MH  - Polymerase Chain Reaction
MH  - Vaccination
EDAT- 1998/06/13 00:00
MHDA- 1998/06/13 00:01
CRDT- 1998/06/13 00:00
PHST- 1998/06/13 00:00 [pubmed]
PHST- 1998/06/13 00:01 [medline]
PHST- 1998/06/13 00:00 [entrez]
AID - S1201-9712(98)90116-3 [pii]
AID - 10.1016/s1201-9712(98)90116-3 [doi]
PST - ppublish
SO  - Int J Infect Dis. 1998 Jan-Mar;2(3):143-6. doi: 10.1016/s1201-9712(98)90116-3.