PMID- 9531898
OWN - NLM
STAT- MEDLINE
DCOM- 19980416
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 69
IP  - 3
DP  - 1998 Mar
TI  - Recurrent in vitro fertilization failure evaluated by fluorescence in situ 
      hybridization: a case report.
PG  - 558-60
AB  - OBJECTIVE: To present a case of IVF failure evaluated by fluorescence in situ 
      hybridization (FISH). DESIGN: Case report. SETTING: Research university 
      laboratory and clinical IVF laboratory. PATIENT(S): An infertile couple with 
      recurrent IVF failure. INTERVENTION(S): Fluorescence in situ hybridization study 
      of the complete cohort of "zygotes" obtained at the third IVF attempt. MAIN 
      OUTCOME MEASURE(S): Fluorescence in situ hybridization studies of chromosomes X, 
      Y, 13, 18, and 21. RESULT(S): All the recovered putative zygotes were abnormal 
      for the expected ploidy, presumably as a result of abnormal oocytes. 
      CONCLUSION(S): Fluorescence in situ hybridization techniques represent a 
      promising approach to analyze zygotes that fail to divide normally in vitro and 
      eggs that fail to become fertilized. In cases of recurrent IVF failure, the 
      results of FISH could be used to counsel couples and thus to help them choose 
      among methods other than IVF for assisted reproduction.
FAU - Grossmann, M
AU  - Grossmann M
AD  - Unitat de Biologia Cel lular, Universitat Autonoma de Barcelona, Spain.
FAU - Calafell, J M
AU  - Calafell JM
FAU - Moreno, V
AU  - Moreno V
FAU - Balasch, J
AU  - Balasch J
FAU - Vanrell, J A
AU  - Vanrell JA
FAU - Egozcue, J
AU  - Egozcue J
FAU - Santalo, J
AU  - Santalo J
FAU - Vidal, F
AU  - Vidal F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, Pair 21
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Infertility/*genetics
MH  - Male
MH  - *Treatment Failure
MH  - X Chromosome
MH  - Y Chromosome
MH  - Zygote/*ultrastructure
EDAT- 1998/04/09 00:00
MHDA- 1998/04/09 00:01
CRDT- 1998/04/09 00:00
PHST- 1998/04/09 00:00 [pubmed]
PHST- 1998/04/09 00:01 [medline]
PHST- 1998/04/09 00:00 [entrez]
AID - S0015-0282(97)00554-2 [pii]
AID - 10.1016/s0015-0282(97)00554-2 [doi]
PST - ppublish
SO  - Fertil Steril. 1998 Mar;69(3):558-60. doi: 10.1016/s0015-0282(97)00554-2.