PMID- 9532351
OWN - NLM
STAT- MEDLINE
DCOM- 19980528
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 43
IP  - 6
DP  - 1998 Mar 15
TI  - Circulating lymphocyte phenotypic surface markers in anxiety disorder patients 
      and normal volunteers.
PG  - 458-63
AB  - BACKGROUND: Although the relationship between stress and immune function is an 
      area of active investigation, there have been few reports studying the 
      relationship between anxiety disorders and the immune system. METHODS: This study 
      employs flow cytometry to measure circulating lymphocyte phenotypic markers in 20 
      medication-free patients with panic disorder, 33 medication-free patients with 
      generalized social phobia, and 32 healthy controls. RESULTS: Both patients with 
      panic disorder and patients with social phobia had increased CD16 (natural 
      killer) cell numbers. Panic disorder patients also had increased numbers of CD19 
      cells (B lymphocytes), human leukocyte antigen (HLA)-DR-presenting cells, and 
      more cells with the combination of HLA-DR and CD19 surface markers (B lymphocytes 
      with HLA-DR on their surface). CONCLUSIONS: These preliminary data suggest that 
      subjects with panic disorder may have alterations in circulating lymphocyte 
      profiles.
FAU - Rapaport, M H
AU  - Rapaport MH
AD  - Department of Psychiatry, UCSD, La Jolla, USA.
LA  - eng
GR  - MH 30914-17/MH/NIMH NIH HHS/United States
GR  - MOI RR00827/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antigens, Surface)
SB  - IM
MH  - Adult
MH  - Antigens, Surface/*physiology
MH  - Anxiety Disorders/*immunology/physiopathology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Lymphocytes/immunology/*physiology
MH  - Male
MH  - Panic Disorder/immunology/physiopathology
MH  - Phenotype
MH  - Phobic Disorders/immunology/physiopathology
MH  - Reference Values
EDAT- 1998/04/09 00:00
MHDA- 1998/04/09 00:01
CRDT- 1998/04/09 00:00
PHST- 1998/04/09 00:00 [pubmed]
PHST- 1998/04/09 00:01 [medline]
PHST- 1998/04/09 00:00 [entrez]
AID - S0006322397002631 [pii]
AID - 10.1016/s0006-3223(97)00263-1 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1998 Mar 15;43(6):458-63. doi: 10.1016/s0006-3223(97)00263-1.