PMID- 9535136
OWN - NLM
STAT- MEDLINE
DCOM- 19980514
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 243
IP  - 1-3
DP  - 1998 Feb 27
TI  - Activation of non-NMDA receptors stimulates acetylcholine and GABA release from 
      dorsal hippocampus: a microdialysis study in the rat.
PG  - 152-6
AB  - The effect of the non-N-methyl-D-aspartate (NMDA) agonists 
      (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and 
      quisqualate (QUIS) on the release of acetylcholine (ACh), gamma-amino butyric 
      acid (GABA), aspartate (Asp) and glutamate (Glu) from the hippocampus of freely 
      moving rats was studied by transversal microdialysis. Intracerebroventricular 
      (i.c.v.) administration of the non-NMDA receptor agonist AMPA (0.5 nmol) enhanced 
      (by about 200%) ACh release from the hippocampus. The effect of AMPA was 
      completely antagonized by 6-nitro-7-sulphamoyl-benz(f)quinoxaline-2,3-dione 
      (NBQX; 2 nmol, i.c.v). No effect was seen when AMPA was perfused through the 
      septum. However, AMPA (200 microM) locally applied to the hippocampus, increased 
      (by about 200%) ACh release. QUIS (200 microM) applied locally to the hippocampus 
      produced a long-lasting increase in the release of ACh (by about 215%) and GABA 
      (by about 460%). Local infusion of tetrodotoxin (1 microM) decreased ACh and GABA 
      basal extracellular levels, and abolished the QUIS-induced increase in ACh and 
      GABA. Our results demonstrate that non-NMDA glutamatergic receptors in the 
      hippocampus regulate hippocampal release of GABA and ACh.
FAU - Giovannini, M G
AU  - Giovannini MG
AD  - Department of Preclinical and Clinical Pharmacology, University of Florence, 
      Italy.
FAU - Rakovska, A
AU  - Rakovska A
FAU - Della Corte, L
AU  - Della Corte L
FAU - Bianchi, L
AU  - Bianchi L
FAU - Pepeu, G
AU  - Pepeu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, AMPA)
RN  - 118876-58-7 (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)
RN  - 4368-28-9 (Tetrodotoxin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/*metabolism
MH  - Animals
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Hippocampus/chemistry/drug effects/*metabolism
MH  - Male
MH  - Microdialysis
MH  - N-Methylaspartate/pharmacology
MH  - Quinoxalines/pharmacology
MH  - Quisqualic Acid/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, AMPA/*physiology
MH  - Tetrodotoxin/pharmacology
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
MH  - gamma-Aminobutyric Acid/*metabolism
EDAT- 1998/04/16 00:00
MHDA- 1998/04/16 00:01
CRDT- 1998/04/16 00:00
PHST- 1998/04/16 00:00 [pubmed]
PHST- 1998/04/16 00:01 [medline]
PHST- 1998/04/16 00:00 [entrez]
AID - S0304-3940(98)00091-3 [pii]
AID - 10.1016/s0304-3940(98)00091-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1998 Feb 27;243(1-3):152-6. doi: 10.1016/s0304-3940(98)00091-3.