PMID- 9538962
OWN - NLM
STAT- MEDLINE
DCOM- 19980521
LR  - 20221207
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 21
IP  - 1
DP  - 1998 Jan
TI  - The effect of short periods of caloric restriction on weight loss and glycemic 
      control in type 2 diabetes.
PG  - 2-8
AB  - OBJECTIVE: To determine whether an intermittent very-low-calorie diet (VLCD) 
      improves weight loss and glycemic control more than moderate caloric restriction 
      alone. RESEARCH DESIGN AND METHODS: Individuals with type 2 diabetes (n = 54) who 
      were > or = 20% over ideal body weight participated in a 20-week behavioral 
      weight control program. Subjects were randomized to either a standard behavioral 
      therapy (SBT) group or to one of two VLCD groups. SBT subjects received a 
      1,500-1,800 kcal/day diet throughout. Both VLCD groups followed a VLCD for 5 
      consecutive days during week 2, followed by either intermittent VLCD therapy for 
      1 day/week for 15 weeks (1-day) or for 5 consecutive days every 5 weeks (5-day), 
      with a 1,500-1,800 kcal/day diet at other times. RESULTS: Both VLCD groups lost 
      more weight than the SBT group over the 20 weeks (P = 0.04). Although the groups 
      did not differ in fasting plasma glucose (FPG) changes at 20 weeks, more subjects 
      in the 5-day group attained a normal HbA1c when compared with the SBT group (P = 
      0.04). This benefit was independent of the effects of weight loss. The best 
      predictor of overall change in FPG and HbA1c was the FPG response during the 
      first 3 weeks of the program. CONCLUSIONS: Periodic VLCDs improved weight loss in 
      diabetic subjects. A regimen with intermittent 5-day VLCD therapy seemed 
      particularly promising, because more subjects in this group attained a normal 
      HbA1c. Moreover, the glucose response to a 3-week period of diet therapy 
      predicted glycemic response at 20 weeks, and it was a better predictor of the 
      20-week response than initial or overall weight loss.
FAU - Williams, K V
AU  - Williams KV
AD  - Department of Medicine, University of Pittsburgh School of Medicine, 
      Pennsylvania, USA. kvw+@.pitt.edu
FAU - Mullen, M L
AU  - Mullen ML
FAU - Kelley, D E
AU  - Kelley DE
FAU - Wing, R R
AU  - Wing RR
LA  - eng
GR  - 2T32-DK-07052-22/DK/NIDDK NIH HHS/United States
GR  - DK-29757/DK/NIDDK NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Behavior Therapy
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus/diet therapy/physiopathology/*therapy
MH  - Diabetes Mellitus, Type 2/diet therapy/physiopathology/*therapy
MH  - *Diet, Reducing
MH  - Energy Intake
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Obesity
MH  - Regression Analysis
MH  - Time Factors
MH  - Triglycerides/blood
MH  - *Weight Loss
EDAT- 1998/04/16 00:00
MHDA- 1998/04/16 00:01
CRDT- 1998/04/16 00:00
PHST- 1998/04/16 00:00 [pubmed]
PHST- 1998/04/16 00:01 [medline]
PHST- 1998/04/16 00:00 [entrez]
AID - 10.2337/diacare.21.1.2 [doi]
PST - ppublish
SO  - Diabetes Care. 1998 Jan;21(1):2-8. doi: 10.2337/diacare.21.1.2.