PMID- 9540286
OWN - NLM
STAT- MEDLINE
DCOM- 19980422
LR  - 20131121
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 107
DP  - 1998 Feb
TI  - Metabolic responses to repeated infusions of identical doses of norepinephrine in 
      chronically energy deficient human subjects.
PG  - 103-8
AB  - The physiological effects of three 30 min infusions of identical doses of 
      norepinephrine (0.15 microgram/kg FFM/min) separated by 60 min intervals were 
      assessed in well nourished (WN; n = 6) and chronically energy deficient (CED; n = 
      6) subjects. Each subject also underwent control, vehicle infusions with 0.9 per 
      cent saline on a separate day. Oxygen consumption (VO2) was significantly higher 
      during the third infusion of NE as compared to the first in both groups. This 
      increment in VO2 occurred despite similar plasma peak NE levels in both 
      infusions. Increments in plasma glucose and free fatty acids were also similar 
      during the first and third infusions. The study demonstrates that thermogenic 
      potentiation which we had earlier demonstrated in WN subjects, occurs in CED 
      subjects as well. Thermogenic potentiation is not associated with altered plasma 
      NE kinetics or mobilisation of substrates.
FAU - Vaz, M
AU  - Vaz M
AD  - Department of Physiology, St John's Medical College, Bangalore.
FAU - Kulkarni, R N
AU  - Kulkarni RN
FAU - Shetty, P S
AU  - Shetty PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - S88TT14065 (Oxygen)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/analysis
MH  - *Energy Metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Norepinephrine/administration & dosage/blood/*pharmacology
MH  - Oxygen/metabolism
EDAT- 1998/04/16 00:00
MHDA- 1998/04/16 00:01
CRDT- 1998/04/16 00:00
PHST- 1998/04/16 00:00 [pubmed]
PHST- 1998/04/16 00:01 [medline]
PHST- 1998/04/16 00:00 [entrez]
PST - ppublish
SO  - Indian J Med Res. 1998 Feb;107:103-8.