PMID- 9540971
OWN - NLM
STAT- MEDLINE
DCOM- 19980504
LR  - 20041117
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 110
IP  - 4
DP  - 1998 Apr
TI  - Local injection of hepatocyte growth factor/scatter factor (HGF/SF) alters cyclic 
      growth of murine hair follicles.
PG  - 338-42
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) has recently been shown to 
      stimulate the hair follicle growth of mouse vibrissae in vitro. In this study, we 
      analyzed the effect of cutaneous injections of recombinant human HGF/SF on hair 
      follicle growth using mice in different hair cycle stages. Five male newborn 
      mice, five male mice in second anagen, and five male mice in second telogen were 
      administered a dorsal intradermal injection of 1 microg HGF/SF dissolved in 0.1% 
      albumin-phosphate-buffered saline once daily for five or seven consecutive days, 
      and then sacrificed on days 7 or 10. Hair follicle growth was evaluated 
      photometrically and histologically using three parameters: the skin color of the 
      reverse side of the resected skin, the skin thickness, and the area occupied by 
      hair follicle tissue. The HGF/SF injected skin of newborn mice had hair follicles 
      that were histologically longer and larger than those of the 0.1% 
      albumin-phosphate-buffered saline injected skin. Mice that had received HGF/SF 
      injection in second anagen, retained anagen hair follicles after 10 d only at the 
      injection site, suggesting that HGF/SF delayed the transition from anagen to 
      telogen. The HGF/SF injected skin of telogen mice had a significant increase in 
      hair follicle tissue in the dermis, suggesting a mild anagen inducible activity 
      by HGF/SF. Furthermore, precise measurements of the 20 hairs plucked from the 
      HGF/SF injection sites revealed mild hair elongation in all the aforementioned 
      experiments. These results imply that HGF/SF acts as a paracrine factor that 
      alters cyclic hair growth of mice.
FAU - Jindo, T
AU  - Jindo T
AD  - Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Tsuboi, R
AU  - Tsuboi R
FAU - Takamori, K
AU  - Takamori K
FAU - Ogawa, H
AU  - Ogawa H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Recombinant Proteins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/growth & development
MH  - Hair/anatomy & histology/drug effects
MH  - Hair Follicle/anatomy & histology/*drug effects/*growth & development
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Humans
MH  - Injections, Intradermal
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Recombinant Proteins
EDAT- 1998/04/16 00:00
MHDA- 1998/04/16 00:01
CRDT- 1998/04/16 00:00
PHST- 1998/04/16 00:00 [pubmed]
PHST- 1998/04/16 00:01 [medline]
PHST- 1998/04/16 00:00 [entrez]
AID - S0022-202X(15)40043-0 [pii]
AID - 10.1046/j.1523-1747.1998.00144.x [doi]
PST - ppublish
SO  - J Invest Dermatol. 1998 Apr;110(4):338-42. doi: 10.1046/j.1523-1747.1998.00144.x.