PMID- 9543172
OWN - NLM
STAT- MEDLINE
DCOM- 19980421
LR  - 20091119
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 83
IP  - 4
DP  - 1998 Apr
TI  - Molecular characterization of the men1 tumor suppressor gene in sporadic 
      pituitary tumors.
PG  - 1388-91
AB  - Anterior pituitary tumors arise sporadically, and also as part of the inherited 
      multiple endocrine neoplasia type 1 (MEN 1) syndrome. To investigate the role of 
      the recently isolated men1 gene in sporadic pituitary tumorigenesis, the complete 
      coding sequence was screened for mutations in 45 sporadic anterior pituitary 
      tumors, including 14 hormone-secreting tumors and 31 nonsecreting tumors, by 
      dideoxy fingerprinting and sequence analysis. No pathogenic sequence changes were 
      found in the men1 coding region. The men1 gene was expressed in 43 of these 
      tumors with sufficient RNA, including one tumor with loss of heterozygosity (LOH) 
      for several polymorphic markers on chromosomal region 11q13. Furthermore, both 
      alleles were expressed in 19 tumors in which the constitutional DNA was 
      heterozygous for intragenic polymorphisms. Thus, inactivation of the men1 tumor 
      suppressor gene, by mutation or by imprinting, does not appear to play a 
      prominent role in sporadic pituitary adenoma pathogenesis.
FAU - Prezant, T R
AU  - Prezant TR
AD  - Division of Endocrinology and Metabolism, Cedars-Sinai Research Institute, 
      University of California, Los Angeles, USA.
FAU - Levine, J
AU  - Levine J
FAU - Melmed, S
AU  - Melmed S
LA  - eng
GR  - DK50238/DK/NIDDK NIH HHS/United States
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Gene Expression Regulation, Neoplastic/*physiology
MH  - *Genes, Tumor Suppressor
MH  - Genetic Testing/methods
MH  - Humans
MH  - *Loss of Heterozygosity
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutation
MH  - *Periodicity
MH  - Pituitary Neoplasms/*genetics
EDAT- 1998/04/29 00:00
MHDA- 1998/04/29 00:01
CRDT- 1998/04/29 00:00
PHST- 1998/04/29 00:00 [pubmed]
PHST- 1998/04/29 00:01 [medline]
PHST- 1998/04/29 00:00 [entrez]
AID - 10.1210/jcem.83.4.4859 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1998 Apr;83(4):1388-91. doi: 10.1210/jcem.83.4.4859.