PMID- 9543229
OWN - NLM
STAT- MEDLINE
DCOM- 19980521
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 341
IP  - 2-3
DP  - 1998 Jan 12
TI  - 'Candyflipping': synergistic discriminative effect of LSD and MDMA.
PG  - 131-4
AB  - The co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 
      3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a 
      prevalence that has allowed for the street terminology 'candyflipping' to 
      describe the combination. Internet sites indicate a significant enhancement of 
      central effects with their simultaneous use. In this preliminary observation, 
      male Fawn-Hooded rats were trained to discriminate 1.5 mg/kg MDMA and were, 
      subsequently, tested with doses of MDMA (0.15 mg/kg) or LSD (0.04 mg/kg) that 
      each produced a saline-like response. Co-administration of these doses of MDMA 
      and LSD synergized to produce a maximal MDMA-like response. The possible 
      mechanism for synergistic action upon central serotonergic neurons is discussed 
      to explain the observed effect.
FAU - Schechter, M D
AU  - Schechter MD
AD  - Department of Pharmacology, Northeastern Ohio Universities College of Medicine, 
      Rootstown 44272-0095, USA. mds@neou-com.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Hallucinogens)
RN  - 0 (Serotonin Agents)
RN  - 8NA5SWF92O (Lysergic Acid Diethylamide)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Discrimination Learning/*drug effects
MH  - Drug Synergism
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Lysergic Acid Diethylamide/administration & dosage/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Serotonin Agents/administration & dosage/*pharmacology
EDAT- 1998/05/23 00:00
MHDA- 1998/05/23 00:01
CRDT- 1998/05/23 00:00
PHST- 1998/05/23 00:00 [pubmed]
PHST- 1998/05/23 00:01 [medline]
PHST- 1998/05/23 00:00 [entrez]
AID - S0014-2999(97)01473-8 [pii]
AID - 10.1016/s0014-2999(97)01473-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1998 Jan 12;341(2-3):131-4. doi: 10.1016/s0014-2999(97)01473-8.