PMID- 9543702
OWN - NLM
STAT- MEDLINE
DCOM- 19980520
LR  - 20131121
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 20
IP  - 1
DP  - 1998 Feb
TI  - Hydrogen peroxide modulation of the superoxide anion production by stimulated 
      neutrophils.
PG  - 103-17
AB  - Hydrogen peroxide (H2O2) pretreatment of human neutrophils results in a 
      suppression of the superoxide anion (O2) production in response to surface-acting 
      stimulants such as lipopolysaccharide (LPS) and opsonized zymosan. This effect 
      was not observed when phorbol myristate acetate (PMA), 
      formyl-methionyl-leucyl-phenylalanine (fMLP) or tumor necrosis factor alpha (TNF 
      alpha) were used as a stimuli. Since the response to PMA and other stimuli was 
      unimpaired by preincubation with H2O2, we assume that the H2O2 modulated O2 
      production is probably due to alteration of the LPS receptor conformation rather 
      than effecting directly NADPH-oxidase. The balance of reactive oxygen species 
      (ROS) produced by neutrophils in the state of sepsis may thus be autoregulated by 
      negative feedback phenomena of locally produced H202.
FAU - Dekaris, I
AU  - Dekaris I
AD  - Department of Ophthalmology, GH "Sveti Duh", Zagreb, Croatia.
FAU - Marotti, T
AU  - Marotti T
FAU - Sprong, R C
AU  - Sprong RC
FAU - van Oirschot, J F
AU  - van Oirschot JF
FAU - van Asbeck, B S
AU  - van Asbeck BS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Reactive Oxygen Species)
RN  - 11062-77-4 (Superoxides)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Humans
MH  - Hydrogen Peroxide/*pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Luminescent Measurements
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neutrophils/*drug effects/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Superoxides/*metabolism
EDAT- 1998/04/17 00:00
MHDA- 1998/04/17 00:01
CRDT- 1998/04/17 00:00
PHST- 1998/04/17 00:00 [pubmed]
PHST- 1998/04/17 00:01 [medline]
PHST- 1998/04/17 00:00 [entrez]
AID - 10.3109/08923979809034811 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 1998 Feb;20(1):103-17. doi: 
      10.3109/08923979809034811.