PMID- 9543704
OWN - NLM
STAT- MEDLINE
DCOM- 19980520
LR  - 20090514
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 20
IP  - 1
DP  - 1998 Feb
TI  - Solanum lyratum inhibits anaphylactic reaction and suppresses the expression of 
      L-histidine decarboxylase mRNA.
PG  - 135-46
AB  - We investigated the effect of aqueous extract of Soloanum lyratum THUNB. 
      (Solanaceae) (SLAE) on anaphylactic reaction. The mast cell is widely thought to 
      contribute to the acute changes associated with anaphylaxis. SLAE inhibited skin 
      mast cells-mediated anaphylactic reaction activated by anti-dinitrophenyl (DNP) 
      IgE. SLAE dose-dependently inhibited histamine release in mouse peritoneal mast 
      cells activated by anti-DNP IgE or substance P. Substance P increased steady 
      state levels of L-histidine decarboxylase (HDC) mRNA in mouse mastocytoma P-815 
      cells. Northern-blot analysis demonstrated that significantly reduced level of 
      the mRNA of HDC was expressed in mast cells treated with SLAE, compared to that 
      without SLAE. We conclude that SLAE directly affect IgE-mediated anaphylactic 
      reaction and substance P-induced HDC mRNA over-expression.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, 
      Chonbuk, South Korea.
FAU - Lee, E J
AU  - Lee EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 33507-63-0 (Substance P)
RN  - EC 4.1.1.22 (Histidine Decarboxylase)
SB  - IM
MH  - Anaphylaxis/*prevention & control
MH  - Animals
MH  - Histamine Release/drug effects
MH  - Histidine Decarboxylase/*antagonists & inhibitors/genetics
MH  - Korea
MH  - *Medicine, East Asian Traditional
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology
MH  - RNA, Messenger/*analysis
MH  - *Solanaceae
MH  - Substance P/pharmacology
EDAT- 1998/04/17 00:00
MHDA- 1998/04/17 00:01
CRDT- 1998/04/17 00:00
PHST- 1998/04/17 00:00 [pubmed]
PHST- 1998/04/17 00:01 [medline]
PHST- 1998/04/17 00:00 [entrez]
AID - 10.3109/08923979809034813 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 1998 Feb;20(1):135-46. doi: 
      10.3109/08923979809034813.