PMID- 9545558
OWN - NLM
STAT- MEDLINE
DCOM- 19980709
LR  - 20190909
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 73
IP  - 1
DP  - 1998 Apr
TI  - Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the 
      developing mouse.
PG  - 117-23
AB  - The basic helix-loop-helix-PAS (bHLH-PAS) protein ARNT is a dimeric partner of 
      the Ah receptor (AHR) and hypoxia inducible factor 1 alpha(HIF1 alpha). These 
      dimers mediate biological responses to xenobiotic exposure and low oxygen 
      tension. The recent cloning of ARNT and HIF1(homologues (ARNT2 and HIF2 alpha) 
      indicates that at least six distinct bHLH-PAS heterodimeric combinations can 
      occur in response to a number of environmental stimuli. In an effort to 
      understand the biological relevance of this combinatorial complexity, we 
      characterized their relative expression at a number of developmental time points 
      by parallel in situ hybridization of adjacent tissue sections. Our results reveal 
      that in general there is limited redundancy in the expression of these six 
      transcription factors and that each of these bHLH-PAS members displays a unique 
      pattern of developmental expression emerging as early as embryonic day 9.5.
CI  - Copyright 1998 Elsevier Science Ireland Ltd.
FAU - Jain, S
AU  - Jain S
AD  - Department of Molecular Pharmacology and Biological Chemistry, Northwestern 
      University Medical School, IL, USA.
FAU - Maltepe, E
AU  - Maltepe E
FAU - Lu, M M
AU  - Lu MM
FAU - Simon, C
AU  - Simon C
FAU - Bradfield, C A
AU  - Bradfield CA
LA  - eng
GR  - ES06883/ES/NIEHS NIH HHS/United States
GR  - P30-CA07175/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Arnt protein, mouse)
RN  - 0 (Arnt2 protein, mouse)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Transcription Factors)
RN  - 138391-32-9 (Aryl Hydrocarbon Receptor Nuclear Translocator)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Aryl Hydrocarbon Receptor Nuclear Translocator
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - DNA-Binding Proteins/biosynthesis/*genetics
MH  - Embryo, Mammalian/*metabolism
MH  - Genes, Overlapping
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nuclear Proteins/biosynthesis/*genetics
MH  - RNA, Messenger/*biosynthesis
MH  - Receptors, Aryl Hydrocarbon/biosynthesis/*genetics
MH  - Transcription Factors/biosynthesis/*genetics
EDAT- 1998/05/28 00:00
MHDA- 1998/05/28 00:01
CRDT- 1998/05/28 00:00
PHST- 1998/05/28 00:00 [pubmed]
PHST- 1998/05/28 00:01 [medline]
PHST- 1998/05/28 00:00 [entrez]
AID - S0925-4773(98)00038-0 [pii]
AID - 10.1016/s0925-4773(98)00038-0 [doi]
PST - ppublish
SO  - Mech Dev. 1998 Apr;73(1):117-23. doi: 10.1016/s0925-4773(98)00038-0.