PMID- 9546070
OWN - NLM
STAT- MEDLINE
DCOM- 19980424
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 102
IP  - 2
DP  - 1998 Apr 15
TI  - Fluorescence in situ hybridization reveals trisomy 2q by insertion into 9p in 
      hepatoblastoma.
PG  - 148-50
AB  - Cytogenetics and fluorescence in situ hybridization (FISH) of a hepatoblastoma 
      are presented. The results of standard chromosome analysis were as follows: 
      47,XY,+2,add(4)(q35),-9,+20[10]. FISH with the use of whole-chromosome paints 
      revealed partial trisomy of the long arm of chromosome 2 by insertion into 
      chromosome 9. Comparison of the G-banded metaphases with metaphase FISH led to a 
      reinterpretation of the karyotype as: 
      47,XY,add(4)(q35),der(9)ins(9;2)(p22;q?21q?25),+20. This case supports previous 
      observations that the critical region of trisomy 2 lies between 2q21 and 2qter 
      and shows how partial trisomy 2q may evade detection in G-banded metaphases.
FAU - Balogh, E
AU  - Balogh E
AD  - Department of Pediatrics, University Medical School, Debrecen, Hungary.
FAU - Swanton, S
AU  - Swanton S
FAU - Kiss, C
AU  - Kiss C
FAU - Jakab, Z S
AU  - Jakab ZS
FAU - Secker-Walker, L M
AU  - Secker-Walker LM
FAU - Olah, E
AU  - Olah E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Child, Preschool
MH  - Chromosome Banding
MH  - *Chromosomes, Human, Pair 2
MH  - *Chromosomes, Human, Pair 9
MH  - Hepatoblastoma/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Liver Neoplasms/*genetics
MH  - Male
MH  - *Trisomy
EDAT- 1998/04/18 00:00
MHDA- 1998/04/18 00:01
CRDT- 1998/04/18 00:00
PHST- 1998/04/18 00:00 [pubmed]
PHST- 1998/04/18 00:01 [medline]
PHST- 1998/04/18 00:00 [entrez]
AID - S016546089700318X [pii]
AID - 10.1016/s0165-4608(97)00318-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1998 Apr 15;102(2):148-50. doi: 
      10.1016/s0165-4608(97)00318-x.