PMID- 9551849
OWN - NLM
STAT- MEDLINE
DCOM- 19980520
LR  - 20190921
IS  - 0742-3098 (Print)
IS  - 0742-3098 (Linking)
VI  - 24
IP  - 3
DP  - 1998 Apr
TI  - Stimulatory effect of melatonin on the 5'-monodeiodinase activity in the liver, 
      kidney, and brown adipose tissue during the early neonatal period of the rabbit.
PG  - 137-41
AB  - The response of type I 5'-monodeiodinase activity (5'-MD) to a s.c. injection or 
      oral administration of melatonin was studied in 3-, 5-, and 7-day-old rabbits. 
      Melatonin-treated animals showed higher activity of the type I 5'-MD in the liver 
      and kidney and of type II 5'-MD in brown adipose tissue (BAT). This respond to 
      melatonin treatment was age dependent. The stimulatory effect of melatonin on 
      renal 5'-MD activity was observed only in 3- and 5-day-old rabbits and in the 
      liver and BAT during the first week of life. Oral melatonin administration tended 
      to exert a more marked effect on enzyme activity than s.c. injection of the 
      hormone. Changes in 5'-MD activities were accompanied by an increase in serum 
      iodothyronine (T4, T3, and rT3) concentrations. The T3 and rT3 increases may 
      result from the deiodinating processes by the type I 5'-MD and 5-MD, 
      respectively, whereas the rise in the serum T4 was probably due to the 
      stimulatory effect of melatonin on the secretory activity of the thyroid gland 
      itself. These results are the first description of the effects evoked by 
      melatonin treatment during the early neonatal period in newborns of the altricial 
      type.
FAU - Brzezinska-Slebodzinska, E
AU  - Brzezinska-Slebodzinska E
AD  - Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 
      Department of Developmental and Experimental Endocrinology, Poznan, Poland.
FAU - Slebodzinski, A B
AU  - Slebodzinski AB
FAU - Styczynska, E
AU  - Styczynska E
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pineal Res
JT  - Journal of pineal research
JID - 8504412
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
RN  - JL5DK93RCL (Melatonin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adipose Tissue, Brown/*drug effects/enzymology
MH  - Administration, Oral
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn/blood
MH  - Female
MH  - Injections, Subcutaneous
MH  - Iodide Peroxidase/*metabolism
MH  - Kidney/*drug effects/enzymology
MH  - Liver/*drug effects/enzymology
MH  - Melatonin/administration & dosage/*pharmacology
MH  - Rabbits
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
EDAT- 1998/04/29 00:00
MHDA- 1998/04/29 00:01
CRDT- 1998/04/29 00:00
PHST- 1998/04/29 00:00 [pubmed]
PHST- 1998/04/29 00:01 [medline]
PHST- 1998/04/29 00:00 [entrez]
AID - 10.1111/j.1600-079x.1998.tb00525.x [doi]
PST - ppublish
SO  - J Pineal Res. 1998 Apr;24(3):137-41. doi: 10.1111/j.1600-079x.1998.tb00525.x.