PMID- 9562048
OWN - NLM
STAT- MEDLINE
DCOM- 19980512
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 17
IP  - 5
DP  - 1998 Apr 15
TI  - Conservation of total T-cell counts during HIV infection: alternative hypotheses 
      and implications.
PG  - 450-7
AB  - While CD4+ T-cell counts in the blood of HIV-infected individuals gradually 
      decrease, there is a parallel increase in the number of blood CD8+ T cells such 
      that the total number of T cells remains essentially constant for several years 
      (1). The basis and significance of this phenomenon are not known. Based on a 
      statistical analysis of longitudinal T-cell counts from the Transfusion Safety 
      Study (TSS) database and on theoretical considerations, we evaluate several 
      alternative models, including versions of the "blind homeostasis" (BH) hypothesis 
      (1-3). At issue is the nature of the homeostatic regulation of lymphocytes and 
      its apparent failure in HIV infection. The most plausible explanation for the 
      conservation of total blood T-cell numbers while subset ratios change is that 
      CD4+ and CD8+ T cells compete for a limited access to the blood compartment. Such 
      interaction between the subsets implies, in particular, that changes in the 
      number of CD4+ T cells occurring in other tissues cannot be reliably inferred 
      from those observed in the blood. We reiterate propositions made earlier (4) that 
      much of the apparent "depletion" of CD4+ lymphocytes during the asymptomatic 
      phase of HIV infection may be attributed to redistribution between the tissues 
      and the blood compartment.
FAU - Grossman, Z
AU  - Grossman Z
AD  - Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv, 
      Israel.
FAU - Herberman, R B
AU  - Herberman RB
FAU - Vatnik, N
AU  - Vatnik N
FAU - Intrator, N
AU  - Intrator N
LA  - eng
GR  - N01-HB-4-7003/HB/NHLBI NIH HHS/United States
GR  - N01-HB-97074/HB/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
SB  - IM
MH  - CD4 Lymphocyte Count
MH  - CD4-CD8 Ratio
MH  - HIV Infections/*blood/immunology/virology
MH  - Homeostasis
MH  - Humans
MH  - Lymphocyte Count
MH  - Models, Biological
MH  - T-Lymphocytes/cytology/*immunology
RF  - 14
EDAT- 1998/04/30 00:00
MHDA- 1998/04/30 00:01
CRDT- 1998/04/30 00:00
PHST- 1998/04/30 00:00 [pubmed]
PHST- 1998/04/30 00:01 [medline]
PHST- 1998/04/30 00:00 [entrez]
AID - 10.1097/00042560-199804150-00010 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):450-7. doi: 
      10.1097/00042560-199804150-00010.