PMID- 9565342
OWN - NLM
STAT- MEDLINE
DCOM- 19980512
LR  - 20190921
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 432
IP  - 4
DP  - 1998 Apr
TI  - Expression of c-Met in laryngeal carcinoma.
PG  - 331-5
AB  - Expression of c-Met, a gene for the hepatocyte growth factor/scatter factor 
      (HGF/SF) receptor, is known to be associated with tumour development in several 
      human carcinomas. The expression of c-Met was examined using immunohistochemistry 
      in 82 cases of primary laryngeal carcinoma to evaluate the tissue distribution of 
      c-Met and the clinicopathological significance of c-Met expression. In normal 
      larynx, c-Met expression was observed only in some minor salivary glands. 
      Positive reaction for c-Met in neoplastic epithelium was noted in 45 out of 82 
      (54.9%) cases. In 44 cases, structures adjacent to the carcinoma (noncancerous 
      squamous epithelium, some stromal fibroblastic cells, and endothelial cells) 
      showed positive reaction for c-Met. c-Met expression in cancerous epithelium was 
      significantly correlated with lymph node status (P<0.04) and proliferating 
      activity expressed by the Ki-67 labelling index (P<0.02). There was no 
      correlation between c-Met expression and age, sex, histological type, T category, 
      distant metastasis or clinical stage. The data suggest that overexpression of 
      c-Met in laryngeal carcinomas represents a growth advantage for cancer cells, 
      which may be conferred by the mitogenic effect of HGF/SF. Simultaneous c-Met 
      expression in noncancerous components of the larynx may represent a paracrine 
      modification of c-Met.
FAU - Sawatsubashi, M
AU  - Sawatsubashi M
AD  - Department of Pathology, Saga Medical School, Nabeshima, Japan.
FAU - Sasatomi, E
AU  - Sasatomi E
FAU - Mizokami, H
AU  - Mizokami H
FAU - Tokunaga, O
AU  - Tokunaga O
FAU - Shin, T
AU  - Shin T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Ki-67 Antigen)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/metabolism
MH  - Laryngeal Neoplasms/*metabolism
MH  - Larynx/*metabolism
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-met/*metabolism
EDAT- 1998/05/16 00:00
MHDA- 1998/05/16 00:01
CRDT- 1998/05/16 00:00
PHST- 1998/05/16 00:00 [pubmed]
PHST- 1998/05/16 00:01 [medline]
PHST- 1998/05/16 00:00 [entrez]
AID - 10.1007/s004280050174 [doi]
PST - ppublish
SO  - Virchows Arch. 1998 Apr;432(4):331-5. doi: 10.1007/s004280050174.