PMID- 9565827
OWN - NLM
STAT- MEDLINE
DCOM- 19980608
LR  - 20131121
IS  - 0300-9831 (Print)
IS  - 0300-9831 (Linking)
VI  - 68
IP  - 2
DP  - 1998
TI  - Modulation of select immune responses by dietary capsaicin.
PG  - 114-9
AB  - Capsaicin (CAP) is the spicy principle of hot peppers that has been used as a 
      food additive, preservative, and medicine. In this study, we investigated the 
      effect of dietary CAP on immune status and selected immune responses. BALB/c mice 
      were divided into 5 groups and fed diets with either 0, 5, 20, 50 or 100 ppm CAP 
      for 3 weeks. The parameters measured with lymphocytes included mitogen-induced 
      proliferation, plaque-forming cell number, and total serum immunoglobulin levels. 
      In spleen cells of mice fed 20 ppm CAP there was a greater T-cell mitogen 
      induced, lymphocyte proliferative response. In addition, the number of 
      antibody-producing B cells and serum IgG and IgM levels increased in mice fed 20 
      ppm CAP as compared to the control with no CAP. The effect of dietary CAP on 
      macrophage activity was assessed by phagocytosis and tumor necrosis factor-alpha 
      (TNF alpha) production. Dietary CAP had no effect on phagocytic activity by 
      peritoneal macrophages, but the levels of secreted TNF alpha increased in the 
      groups fed 20 ppm CAP compared to the control. These results suggest that dietary 
      CAP may differentially enhance immune status as well as select immune functions. 
      That is in contrast with previous studies that show immunosuppression observed 
      after CAP injection.
FAU - Yu, R
AU  - Yu R
AD  - Department of Food and Nutrition, University of Ulsan, Korea.
FAU - Park, J W
AU  - Park JW
FAU - Kurata, T
AU  - Kurata T
FAU - Erickson, K L
AU  - Erickson KL
LA  - eng
GR  - CA 47050/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Int J Vitam Nutr Res
JT  - International journal for vitamin and nutrition research. Internationale 
      Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de 
      vitaminologie et de nutrition
JID - 1273304
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulins)
RN  - 0 (Mitogens)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology
MH  - Capsaicin/administration & dosage/*pharmacology
MH  - *Diet
MH  - Female
MH  - Immunity/*drug effects
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Immunoglobulins/blood
MH  - Lymphocyte Activation/drug effects
MH  - Macrophages/drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mitogens/pharmacology
MH  - Phagocytosis/drug effects
MH  - T-Lymphocytes/immunology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 1998/05/05 00:00
MHDA- 1998/05/05 00:01
CRDT- 1998/05/05 00:00
PHST- 1998/05/05 00:00 [pubmed]
PHST- 1998/05/05 00:01 [medline]
PHST- 1998/05/05 00:00 [entrez]
PST - ppublish
SO  - Int J Vitam Nutr Res. 1998;68(2):114-9.