PMID- 9566413
OWN - NLM
STAT- MEDLINE
DCOM- 19980507
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 50
IP  - 4
DP  - 1998 Apr
TI  - In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 
      matched controls.
PG  - 1149-52
AB  - We investigated cytokine levels (interleukin [IL]-1beta, IL-1ra, IL-2, IL-6, 
      tumor necrosis factor [TNF]-alpha, TNF-beta) in plasma and secreted by 
      mitogen-stimulated blood monocytes and lymphocytes; T-cell subsets; and natural 
      killer cell activity in patients with narcolepsy and in human leukocyte antigen 
      (HLA)-DR2 matched controls. The only significant finding was higher IL-6 
      secretion by monocytes of patients than by those of the HLA-DR2-positive 
      controls. In conclusion, we found no major abnormalities of T-cell function in 
      patients with narcolepsy, but slight alterations of monocyte function deserving 
      further investigation.
FAU - Hinze-Selch, D
AU  - Hinze-Selch D
AD  - Clinical Institute, Max Planck Institute of Psychiatry, Munich, Germany.
FAU - Wetter, T C
AU  - Wetter TC
FAU - Zhang, Y
AU  - Zhang Y
FAU - Lu, H C
AU  - Lu HC
FAU - Albert, E D
AU  - Albert ED
FAU - Mullington, J
AU  - Mullington J
FAU - Wekerle, H
AU  - Wekerle H
FAU - Holsboer, F
AU  - Holsboer F
FAU - Pollmacher, T
AU  - Pollmacher T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-6)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Female
MH  - HLA-DR2 Antigen/*analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/metabolism
MH  - Interleukin-2/metabolism
MH  - Interleukin-6/metabolism
MH  - Lymphotoxin-alpha/metabolism
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/*immunology
MH  - Sialoglycoproteins/metabolism
MH  - Sleep, REM/immunology
MH  - T-Lymphocyte Subsets/*immunology/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1998/05/05 00:00
MHDA- 1998/05/05 00:01
CRDT- 1998/05/05 00:00
PHST- 1998/05/05 00:00 [pubmed]
PHST- 1998/05/05 00:01 [medline]
PHST- 1998/05/05 00:00 [entrez]
AID - 10.1212/wnl.50.4.1149 [doi]
PST - ppublish
SO  - Neurology. 1998 Apr;50(4):1149-52. doi: 10.1212/wnl.50.4.1149.