PMID- 9566613
OWN - NLM
STAT- MEDLINE
DCOM- 19980619
LR  - 20190822
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 23
IP  - 5
DP  - 1998 May
TI  - Choline administration reverses hypotension in spinal cord transected rats: the 
      involvement of vasopressin.
PG  - 733-41
AB  - Intracerebroventricular (i.c.v.) choline (50-150 microg) increased blood pressure 
      and decreased heart rate in spinal cord transected, hypotensive rats. Choline 
      administered intraperitoneally (60 mg/kg), also, increased blood pressure, but to 
      a lesser extent. The pressor response to i.c.v. choline was associated with an 
      increase in plasma vasopressin. Mecamylamine pretreatment (50 microg; i.c.v.) 
      blocked the pressor, bradycardic and vasopressin responses to choline (150 
      microg). Atropine pretreatment (10 microg; i.c.v.) abolished the bradycardia but 
      failed to alter pressor and vasopressin responses. Hemicholinium-3 [HC-3 (20 
      microg; i.c.v.)] pretreatment attenuated both bradycardia and pressor responses 
      to choline. The vasopressin V1 receptor antagonist, 
      (beta-mercapto-beta,beta-cyclopenta-methylenepropionyl1, O-Me-Tyr2, 
      Arg8)-vasopressin (10 microg/kg) administered intravenously 5 min after choline 
      abolished the pressor response and attenuated the bradycardia-induced by choline. 
      These data show that choline restores hypotension effectively by activating 
      central nicotinic receptors via presynaptic mechanisms, in spinal shock. 
      Choline-induced bradycardia is mediated by central nicotinic and muscarinic 
      receptors. Increase in plasma vasopressin is involved in cardiovascular effects 
      of choline.
FAU - Savci, V
AU  - Savci V
AD  - Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey. 
      vsavci@uu20.bim.uludag.edu.tr
FAU - Ulus, I H
AU  - Ulus IH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Antidiuretic Hormone Receptor Antagonists)
RN  - 0 (Hormone Antagonists)
RN  - 11000-17-2 (Vasopressins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 312-45-8 (Hemicholinium 3)
RN  - 73168-24-8 (vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- 
      methyl-L-tyrosine)-8-L-arginine-)
RN  - 7C0697DR9I (Atropine)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Animals
MH  - Antidiuretic Hormone Receptor Antagonists
MH  - Arginine Vasopressin/analogs & derivatives/pharmacology
MH  - Atropine/administration & dosage/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Cerebral Ventricles/drug effects/physiology/*physiopathology
MH  - Choline/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/*drug effects
MH  - Hemicholinium 3/administration & dosage/pharmacology
MH  - Hormone Antagonists/pharmacology
MH  - Hypotension/*drug therapy/etiology/physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Spinal Cord/*physiology
MH  - Spinal Cord Injuries/*physiopathology
MH  - Time Factors
MH  - Vasopressins/*blood
EDAT- 1998/05/05 00:00
MHDA- 1998/05/05 00:01
CRDT- 1998/05/05 00:00
PHST- 1998/05/05 00:00 [pubmed]
PHST- 1998/05/05 00:01 [medline]
PHST- 1998/05/05 00:00 [entrez]
AID - 10.1023/a:1022407409727 [doi]
PST - ppublish
SO  - Neurochem Res. 1998 May;23(5):733-41. doi: 10.1023/a:1022407409727.