PMID- 9570914
OWN - NLM
STAT- MEDLINE
DCOM- 19980717
LR  - 20161124
IS  - 0147-6513 (Print)
IS  - 0147-6513 (Linking)
VI  - 39
IP  - 3
DP  - 1998 Mar
TI  - The acute toxicity of selected alkylphenols to young and adult Daphnia magna.
PG  - 227-32
AB  - Differences in sensitivity toward toxicants between young and adult individuals 
      in a population are assumed to be primarily associated with their difference in 
      body size. This assumption plays a key role in the modeling of effects of 
      variable concentrations of toxicants on nonhomogeneous populations. The 
      hazard-based no-effect-concentrations (NECs), killing rates, and elimination 
      rates, estimated from the survival data of a series of acute toxicity tests with 
      young and adults of Daphnia magna and six alkylphenols, were used to evaluated 
      this assumption. The results lead to the conclusion that young and adult D. magna 
      were equally sensitive in terms of NEC and killing rate and that the observed 
      differences in elimination rates could be explained on the basis of a difference 
      in body size. Furthermore, it was found that elimination rates estimated on the 
      basis of the survival data were consistently smaller than those expected on the 
      basis of a QSAR for Daphnia pulex, a comparable species. This discrepancy was 
      likely due to a decreased uptake and elimination during a period of 
      immobilization prior to death. Since it is unknown to what extent immobilized 
      individuals are able to recover from short-term exposures, the observed deviation 
      clearly identifies a complicating factor in the modeling of effects of variable 
      concentrations of toxicants.
FAU - Gerritsen, A
AU  - Gerritsen A
AD  - Department of Environmental Toxicology, TNO-Toxicology, Delft, The Netherlands.
FAU - van der Hoeven, N
AU  - van der Hoeven N
FAU - Pielaat, A
AU  - Pielaat A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Hazardous Substances)
RN  - 0 (Phenols)
RN  - 7DF2B8LH3P (4-octylphenol)
RN  - I03GBV4WEL (4-nonylphenol)
RN  - O81VMW36CV (butylphen)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Daphnia/*metabolism
MH  - Female
MH  - Hazardous Substances/analysis/*toxicity
MH  - Hydrogen-Ion Concentration
MH  - Phenols/analysis/*toxicity
MH  - Structure-Activity Relationship
MH  - Toxicity Tests
EDAT- 1998/05/08 00:00
MHDA- 1998/05/08 00:01
CRDT- 1998/05/08 00:00
PHST- 1998/05/08 00:00 [pubmed]
PHST- 1998/05/08 00:01 [medline]
PHST- 1998/05/08 00:00 [entrez]
AID - S0147-6513(97)91578-5 [pii]
AID - 10.1006/eesa.1997.1578 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 1998 Mar;39(3):227-32. doi: 10.1006/eesa.1997.1578.