PMID- 9572589
OWN - NLM
STAT- MEDLINE
DCOM- 19980616
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 244
IP  - 2
DP  - 1998 Mar 13
TI  - N-methyl-D-aspartate receptors are expressed by intrinsic neurons of rat larynx 
      and esophagus.
PG  - 77-80
AB  - Overactivation of N-methyl-D-aspartate receptors (NMDAR), a mechanism of central 
      neurotoxicity, has recently been shown to increase airway responsiveness in rat 
      lungs. NMDAR have not been localized in the airways, but neurons of the myenteric 
      plexus in the rat express mRNA for NMDAR. Furthermore, a population of 
      glutamate-containing cell bodies in the nucleus ambiguus projects to the rat 
      larynx. On this basis, we hypothesized that some postganglionic parasympathetic 
      neurons of the larynx, trachea and esophagus may express NMDAR. Sections of rat 
      larynx, trachea and esophagus were immunocytochemically labeled for NMDAR subtype 
      2B using a specific antibody. NMDAR immunoreactivity was observed in cell bodies 
      of individual neurons located in the submucosa and on the external surface of 
      skeletal muscle in the larynx and also in neurons of the esophageal plexus. All 
      NMDAR-positive nerve cell bodies also contained immunoreactivity for vasoactive 
      intestinal peptide (VIP) and some were immunoreactive for nitric oxide synthase 
      (NOS). None of the cell bodies of the tracheal plexus contained NMDAR 
      immunoreactivity. The findings demonstrate that NMDAR are expressed in neurons of 
      the rat larynx and esophagus and their activation may be associate with VIP or NO 
      release.
FAU - Robertson, B S
AU  - Robertson BS
AD  - Department of Anatomy, West Virginia University, Morgantown 26506, USA.
FAU - Satterfield, B E
AU  - Satterfield BE
FAU - Said, S I
AU  - Said SI
FAU - Dey, R D
AU  - Dey RD
LA  - eng
GR  - HL 55849/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Esophagus/*innervation
MH  - Immunohistochemistry
MH  - Laryngeal Nerves/*metabolism
MH  - Male
MH  - Muscle, Skeletal/innervation
MH  - Nerve Fibers/metabolism/ultrastructure
MH  - Neurons/cytology/*metabolism
MH  - Nitric Oxide Synthase/analysis
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, N-Methyl-D-Aspartate/*biosynthesis
MH  - Trachea/*innervation
MH  - Transcription, Genetic
MH  - Vasoactive Intestinal Peptide/analysis
EDAT- 1998/05/08 00:00
MHDA- 1998/05/08 00:01
CRDT- 1998/05/08 00:00
PHST- 1998/05/08 00:00 [pubmed]
PHST- 1998/05/08 00:01 [medline]
PHST- 1998/05/08 00:00 [entrez]
AID - S0304-3940(98)00130-X [pii]
AID - 10.1016/s0304-3940(98)00130-x [doi]
PST - ppublish
SO  - Neurosci Lett. 1998 Mar 13;244(2):77-80. doi: 10.1016/s0304-3940(98)00130-x.