PMID- 9573123
OWN - NLM
STAT- MEDLINE
DCOM- 19980514
LR  - 20240214
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 66
IP  - 5
DP  - 1998 May
TI  - Production of monocyte chemoattractant protein 1 in tuberculosis patients.
PG  - 2319-22
AB  - To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the 
      immune response to Mycobacterium tuberculosis, we studied MCP-1 production in 
      tuberculosis patients. CD14+ blood monocytes from tuberculosis patients 
      spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ 
      monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from 
      tuberculosis patients was also markedly increased. These findings suggest that 
      MCP-1 can contribute to the antimycobacterial inflammatory response by attracting 
      monocytes and T lymphocytes.
FAU - Lin, Y
AU  - Lin Y
AD  - Department of Medicine, University of Southern California School of Medicine, Los 
      Angeles 90033, USA.
FAU - Gong, J
AU  - Gong J
FAU - Zhang, M
AU  - Zhang M
FAU - Xue, W
AU  - Xue W
FAU - Barnes, P F
AU  - Barnes PF
LA  - eng
GR  - Z01 AI005074/ImNIH/Intramural NIH HHS/United States
GR  - AI27285/AI/NIAID NIH HHS/United States
GR  - AI36069/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Lipopolysaccharide Receptors/analysis
MH  - Monocytes/metabolism
MH  - RNA, Messenger/analysis
MH  - Tuberculosis, Pulmonary/*immunology/metabolism
PMC - PMC108197
EDAT- 1998/05/09 00:00
MHDA- 1998/05/09 00:01
PMCR- 1998/05/01
CRDT- 1998/05/09 00:00
PHST- 1998/05/09 00:00 [pubmed]
PHST- 1998/05/09 00:01 [medline]
PHST- 1998/05/09 00:00 [entrez]
PHST- 1998/05/01 00:00 [pmc-release]
AID - 1627 [pii]
AID - 10.1128/IAI.66.5.2319-2322.1998 [doi]
PST - ppublish
SO  - Infect Immun. 1998 May;66(5):2319-22. doi: 10.1128/IAI.66.5.2319-2322.1998.