PMID- 9573336
OWN - NLM
STAT- MEDLINE
DCOM- 19980625
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 211
IP  - 1
DP  - 1998 Apr 28
TI  - Diverse modes of alternative splicing of human splicing factor SF1 deduced from 
      the exon-intron structure of the gene.
PG  - 29-37
AB  - Several cDNAs encoding the essential human splicing facor (SF) 1 have been 
      cloned. Comparison of the cDNA sequences suggested that the corresponding mRNAs 
      are generated by alternative splicing from a common pre-mRNA. To confirm this 
      assumption and to analyze possible modes used in the generation of these mRNAs, 
      we have determined the structure of the gene encoding SF1. The gene extends over 
      approximately 15kb and contains 14 exons. The exon/intron structure and sequences 
      at the splice sites are highly conserved in the corresponding mouse gene. The 
      human SF1 gene is located on chromosome 11 close to the gene encoding Menin, 
      recently identified as the gene responsible for multiple endocrine neoplasia-type 
      1 (MEN1). The absence of a TATA box in the 5' flanking region of the SF1 
      transcription unit suggests that the SF1 gene represents a housekeeping gene. 
      However, genomic sequence analysis revealed putative binding sites for regulatory 
      transcription factors upstream of the 5' end of the cDNA. Analysis of the SF1 
      genomic and cDNA sequences predicts the use of duplicated 5' and 3' splice sites 
      as well as exon skipping and intron inclusion to generate six SF1 mRNAs by 
      alternative splicing events.
FAU - Kramer, A
AU  - Kramer A
AD  - Department de Biologie Cellulaire, Universite de Geneve, Geneva, Switzerland. 
      kraemer@cellbio.unige.ch
FAU - Quentin, M
AU  - Quentin M
FAU - Mulhauser, F
AU  - Mulhauser F
LA  - eng
SI  - GENBANK/AJ000051
SI  - GENBANK/AJ000052
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RNA Precursors)
RN  - 0 (RNA Splicing Factors)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (SF1 protein, human)
RN  - 0 (Sf1 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Alternative Splicing/*genetics
MH  - Base Sequence
MH  - Binding Sites/genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11
MH  - Cloning, Molecular
MH  - *DNA-Binding Proteins
MH  - Exons/genetics
MH  - Humans
MH  - Introns/genetics
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - RNA Precursors/genetics
MH  - RNA Splicing/genetics
MH  - RNA Splicing Factors
MH  - RNA-Binding Proteins/*genetics
MH  - Sequence Analysis, DNA
MH  - Transcription Factors/genetics
MH  - Transcription, Genetic/genetics
EDAT- 1998/05/29 00:00
MHDA- 1998/05/29 00:01
CRDT- 1998/05/29 00:00
PHST- 1998/05/29 00:00 [pubmed]
PHST- 1998/05/29 00:01 [medline]
PHST- 1998/05/29 00:00 [entrez]
AID - S0378-1119(98)00058-4 [pii]
AID - 10.1016/s0378-1119(98)00058-4 [doi]
PST - ppublish
SO  - Gene. 1998 Apr 28;211(1):29-37. doi: 10.1016/s0378-1119(98)00058-4.