PMID- 9573398
OWN - NLM
STAT- MEDLINE
DCOM- 19980619
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 789
IP  - 2
DP  - 1998 Apr 13
TI  - Serotonin-induced population primary afferent depolarisation in vitro: the 
      effects of neonatal capsaicin treatment.
PG  - 339-42
AB  - The effect of 5-hydroxytryptamine (5-HT) on population primary afferent 
      depolarisation (PAD) has been studied using in vitro spinal cord preparations 
      from normal and capsaicin pre-treated (neonatal subcutaneous injection; 75 mg 
      kg-1) rats aged 10-14 days. In preparations from untreated rats, the 
      concentration-response curve for PAD in response to 0.1-100 microM 5-HT was 
      bell-shaped but in the capsaicin pre-treated group, a non-saturating 5-HT-induced 
      PAD concentration-response curve was generated. Quantitatively, the mean PAD 
      responses to 0.1-10 microM 5-HT were of a greater amplitude in the control group 
      compared to the capsaicin pre-treated group (p</=0. 05). For the highest 5-HT 
      concentration of 100 microM, PAD values were significantly greater in the 
      capsaicin pre-treated group (p</=0. 05). These data indicate that control of 
      sensory afferent polarity may involve two 5-HT receptor types and that 
      nociceptive and non-nociceptive afferents may be targets for released 5-HT.
CI  - Copyright 1998 Elsevier Science B.V.
FAU - Khasabov, S G
AU  - Khasabov SG
AD  - Dept. of Physiology, University of Leeds, Leeds LS2 9NQ, UK.
FAU - Lopez-Garcia, J A
AU  - Lopez-Garcia JA
FAU - King, A E
AU  - King AE
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 333DO1RDJY (Serotonin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Capsaicin/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Electrophysiology
MH  - Neurons, Afferent/*drug effects/*physiology
MH  - Nociceptors/drug effects/physiology
MH  - Osmolar Concentration
MH  - Rats
MH  - Serotonin/*pharmacology
MH  - Spinal Cord/cytology/physiology
MH  - gamma-Aminobutyric Acid/pharmacology
EDAT- 1998/05/30 00:00
MHDA- 1998/05/30 00:01
CRDT- 1998/05/30 00:00
PHST- 1998/05/30 00:00 [pubmed]
PHST- 1998/05/30 00:01 [medline]
PHST- 1998/05/30 00:00 [entrez]
AID - S0006-8993(98)00136-X [pii]
AID - 10.1016/s0006-8993(98)00136-x [doi]
PST - ppublish
SO  - Brain Res. 1998 Apr 13;789(2):339-42. doi: 10.1016/s0006-8993(98)00136-x.