PMID- 9577964
OWN - NLM
STAT- MEDLINE
DCOM- 19980618
LR  - 20180213
IS  - 1015-2008 (Print)
IS  - 1015-2008 (Linking)
VI  - 66
IP  - 1
DP  - 1998
TI  - Biological basis of the HLA-B8,DR3-associated progression of acquired immune 
      deficiency syndrome.
PG  - 33-7
AB  - The factors influencing the evolution of human immunodeficiency virus (HIV) 
      infection are not fully known, but the host genotype undoubtedly plays a role in 
      determining the outcome of the disease by affecting the immune response to HIV. 
      The role of the host human leukocyte antigen (HLA) genotype in the regulation of 
      susceptibility to HIV infection and expression has been studied extensively in 
      different major risk groups. Certain HLA alleles and haplotypes, being associated 
      with aberrant immune responses independently from HIV infection, have been 
      reported to facilitate the rapid progression of disorders related to HIV 
      infection. Particularly, the association of rapid acquired immunodeficiency 
      syndrome (AIDS) progression with genes from the HLA-B8,DR3 haplotype has been 
      reported by different research groups. It is well known that this haplotype is 
      associated in all Caucasian populations with a wide variety of diseases with 
      autoimmune features and in healthy subjects with a number of immune system 
      dysfunctions, as a reduced production of T helper (Th)1 type cytokine. HIV 
      infection may act on this genetic background triggering immunopathogenetic 
      mechanisms leading to AIDS with a dominant Th2 profile as a common feature.
FAU - Candore, G
AU  - Candore G
AD  - Istituti di Patologia Generale, Universita di Palermo, Italia.
FAU - Romano, G C
AU  - Romano GC
FAU - D'Anna, C
AU  - D'Anna C
FAU - Di Lorenzo, G
AU  - Di Lorenzo G
FAU - Gervasi, F
AU  - Gervasi F
FAU - Lio, D
AU  - Lio D
FAU - Modica, M A
AU  - Modica MA
FAU - Potestio, M
AU  - Potestio M
FAU - Caruso, C
AU  - Caruso C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DR3 Antigen)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/genetics/*immunology
MH  - Disease Progression
MH  - Disease Susceptibility
MH  - Genotype
MH  - HLA-B8 Antigen/*genetics
MH  - HLA-DR3 Antigen/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Th2 Cells/immunology
EDAT- 1998/05/13 02:03
MHDA- 2000/10/06 11:01
CRDT- 1998/05/13 02:03
PHST- 1998/05/13 02:03 [pubmed]
PHST- 2000/10/06 11:01 [medline]
PHST- 1998/05/13 02:03 [entrez]
AID - pat66033 [pii]
AID - 10.1159/000027992 [doi]
PST - ppublish
SO  - Pathobiology. 1998;66(1):33-7. doi: 10.1159/000027992.