PMID- 9582002
OWN - NLM
STAT- MEDLINE
DCOM- 19980610
LR  - 20220408
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 60
IP  - 2
DP  - 1998 Mar
TI  - Effect of Syzygium aromaticum extract on immediate hypersensitivity in rats.
PG  - 125-31
AB  - We investigated the effect of aqueous extract of Syzygium aromaticum (L.) Merr. 
      et Perry (Myrtaceae) flower bud (SAFB) on immediate hypersensitivity. SAFB 
      inhibited compound 48/80-induced systemic anaphylaxis in rats (IC50 = 31.25 
      mg/kg, i.p.). SAFB also inhibited local immunoglobulin E (IgE)-mediated passive 
      cutaneous anaphylactic reaction (IC50 = 17.78 mg/kg, i.v.; IC50 = 19.81 mg/kg, 
      p.o.). When SAFB was pretreated at concentrations ranging from 25 to 1000 mg/kg, 
      the serum histamine levels were reduced in a dose-dependent manner. Moreover, 
      SAFB dose-dependently inhibited histamine release from rat peritoneal mast cells 
      (RPMC) by compound 48/80 or anti-dinitrophenyl IgE. When SAFB was added, the 
      level of cAMP in RPMC transiently and significantly increased about 47-fold at 10 
      s compared with that of basal cells. These results indicate that SAFB inhibits 
      immediate hypersensitivity by inhibition of histamine release from mast cells in 
      vivo and in vitro.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, 
      Chonbuk, South Korea.
FAU - Lee, E H
AU  - Lee EH
FAU - Hong, S H
AU  - Hong SH
FAU - Song, H J
AU  - Song HJ
FAU - Shin, M K
AU  - Shin MK
FAU - Kim, S H
AU  - Kim SH
FAU - Shin, T Y
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Cyclic AMP/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Histamine/blood
MH  - Hypersensitivity, Immediate/chemically induced/*drug therapy
MH  - Mast Cells/drug effects/metabolism
MH  - Peritoneal Cavity/cytology
MH  - Plant Extracts/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 1998/05/15 00:00
MHDA- 1998/05/15 00:01
CRDT- 1998/05/15 00:00
PHST- 1998/05/15 00:00 [pubmed]
PHST- 1998/05/15 00:01 [medline]
PHST- 1998/05/15 00:00 [entrez]
AID - S0378874197001438 [pii]
AID - 10.1016/s0378-8741(97)00143-8 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 1998 Mar;60(2):125-31. doi: 10.1016/s0378-8741(97)00143-8.