PMID- 9584337
OWN - NLM
STAT- MEDLINE
DCOM- 19980623
LR  - 20191111
IS  - 0928-1231 (Print)
IS  - 0928-1231 (Linking)
VI  - 20
IP  - 2
DP  - 1998 Apr
TI  - Continuous infusion of chemotherapy: focus on 5-fluorouracil and 
      fluorodeoxyuridine.
PG  - 45-59
AB  - Continuous infusion of chemotherapy is one of the developments to try to improve 
      the treatment of metastatic cancer. There is a sound theoretical rationale to 
      deliver cytotoxic drugs as a continuous infusion. Furthermore, the development of 
      reliable venous access devices and portable infusion pumps enables patients to be 
      treated in an ambulatory setting. This review focuses on the continuous infusion 
      of the most frequently used drugs: 5-fluorouracil (5-FU) and fluorodeoxyuridine 
      (FUDR). An overview is given of both preclinical studies and studies in humans. 
      Continuous infusion of 5-FU and FUDR has proven to be feasible in all studies. 
      However, the results (response rate and especially survival) are rather 
      disappointing. So far, continuous infusion of cytostatic drugs can still be 
      considered as an experimental procedure. Whether protracted, intermittent of 
      circadian modulated continuous infusion is the optimal treatment schedule has 
      still to be proven in future studies. Furthermore, studies are needed to 
      demonstrate whether dose intensity for most tumours is important for treatment 
      outcome. Also, studies are needed to investigate quality of life and economic 
      issues.
FAU - Poorter, R L
AU  - Poorter RL
AD  - Department of Radiotherapy, Academic Hospital Vrije Universiteit, Amsterdam, The 
      Netherlands.
FAU - Bakker, P J
AU  - Bakker PJ
FAU - Veenhof, C H
AU  - Veenhof CH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Pharm World Sci
JT  - Pharmacy world & science : PWS
JID - 9307352
RN  - 0 (Antimetabolites, Antineoplastic)
RN  - 0 (Antineoplastic Agents)
RN  - 039LU44I5M (Floxuridine)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Animals
MH  - Antimetabolites, Antineoplastic/*administration & dosage/*therapeutic use
MH  - Antineoplastic Agents/*administration & dosage/*therapeutic use
MH  - Floxuridine/*administration & dosage/*therapeutic use
MH  - Fluorouracil/*administration & dosage/*therapeutic use
MH  - Humans
MH  - Infusions, Intravenous
RF  - 101
EDAT- 1998/05/19 00:00
MHDA- 1998/05/19 00:01
CRDT- 1998/05/19 00:00
PHST- 1998/05/19 00:00 [pubmed]
PHST- 1998/05/19 00:01 [medline]
PHST- 1998/05/19 00:00 [entrez]
AID - 10.1023/a:1008605600414 [doi]
PST - ppublish
SO  - Pharm World Sci. 1998 Apr;20(2):45-59. doi: 10.1023/a:1008605600414.