PMID- 9585056
OWN - NLM
STAT- MEDLINE
DCOM- 19980521
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 126
IP  - 2
DP  - 1998 Apr 24
TI  - Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma.
PG  - 119-26
AB  - A recurrent reciprocal chromosomal translocation, t(12;14)(q15;q24) is frequently 
      observed in uterine leiomyoma. Chromosome 12 breakpoints have been shown to occur 
      in a region of approximately 150 kb that contains the gene for a high mobility 
      group protein (HMGI-C). The breakpoint region on chromosome 14 has not been 
      precisely defined. We have generated a contig of overlapping yeast artificial 
      chromosome (YAC) clones approximately 3 Mb in size. Fluorescence in situ 
      hybridization (FISH) analysis showed that this contig spanned the t(12;14) 
      breakpoints in three uterine leiomyomas and that the breakpoints in these tumors 
      occurred within a 1 Mb region. A 30 kb cosmid spanning one of the breakpoints was 
      isolated to set the stage for identifying regions on chromosome 14 that may cause 
      this region to be a preferential site for chromosomal translocation.
FAU - Bhugra, B
AU  - Bhugra B
AD  - Department of Molecular Genetics, Biochemistry, and Microbiology, University of 
      Cincinnati College of Medicine, OH 45267-0524, USA.
FAU - Smolarek, T A
AU  - Smolarek TA
FAU - Lynch, R A
AU  - Lynch RA
FAU - Meloni, A M
AU  - Meloni AM
FAU - Sandberg, A A
AU  - Sandberg AA
FAU - Deaven, L
AU  - Deaven L
FAU - Menon, A G
AU  - Menon AG
LA  - eng
GR  - CA67315/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Cloning, Molecular
MH  - DNA, Neoplasm/*genetics
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - Karyotyping
MH  - Leiomyoma/*genetics
MH  - Polymerase Chain Reaction
MH  - Translocation, Genetic/*genetics
MH  - Uterine Neoplasms/*genetics
EDAT- 1998/05/19 00:00
MHDA- 1998/05/19 00:01
CRDT- 1998/05/19 00:00
PHST- 1998/05/19 00:00 [pubmed]
PHST- 1998/05/19 00:01 [medline]
PHST- 1998/05/19 00:00 [entrez]
AID - S0304-3835(97)00478-3 [pii]
AID - 10.1016/s0304-3835(97)00478-3 [doi]
PST - ppublish
SO  - Cancer Lett. 1998 Apr 24;126(2):119-26. doi: 10.1016/s0304-3835(97)00478-3.