PMID- 9585175
OWN - NLM
STAT- MEDLINE
DCOM- 19980526
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 62
IP  - 16
DP  - 1998
TI  - Inhibitory effects of tyrosine kinase inhibitors on capacitative Ca2+ entry in 
      rat glioma C6 cells.
PG  - PL271-6
AB  - The effects of genistein and erbstatin analogue, inhibitors of tyrosine kinase, 
      on Ca2+ mobilization evoked by thapsigargin (TG) were examined in rat glioma C6 
      cells. Genistein and erbstatin analogue inhibited the Ca2+ release from 
      intracellular pools as well as Ca2+ entry from extracellular medium evoked by TG 
      in a dose-dependent manner. However, they did not affect a Ca2+ entry due to 
      leakage of Ca2+ from extracellular medium into cells. The present results suggest 
      that tyrosine kinase inhibitors inhibit capacitative Ca2+ entry due to the 
      inhibition of both Ca2+ entry itself and Ca2+ release in rat glioma C6 cells.
FAU - Takemura, H
AU  - Takemura H
AD  - Department of Pharmacology, School of Medicine, Sapporo Medical University, 
      Japan.
FAU - Sakano, S
AU  - Sakano S
FAU - Kaneko, M
AU  - Kaneko M
FAU - Ohshika, H
AU  - Ohshika H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Hydroquinones)
RN  - 67526-95-8 (Thapsigargin)
RN  - DH2M523P0H (Genistein)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - SY7Q814VUP (Calcium)
RN  - WDH83K6T5P (erbstatin)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Enzyme Inhibitors/*pharmacology
MH  - Genistein/*pharmacology
MH  - Glioma/enzymology/*metabolism
MH  - Hydroquinones/*pharmacology
MH  - Protein-Tyrosine Kinases/*antagonists & inhibitors
MH  - Rats
MH  - Thapsigargin/pharmacology
MH  - Tumor Cells, Cultured/drug effects
EDAT- 1998/05/19 00:00
MHDA- 1998/05/19 00:01
CRDT- 1998/05/19 00:00
PHST- 1998/05/19 00:00 [pubmed]
PHST- 1998/05/19 00:01 [medline]
PHST- 1998/05/19 00:00 [entrez]
AID - S0024320598000861 [pii]
AID - 10.1016/s0024-3205(98)00086-1 [doi]
PST - ppublish
SO  - Life Sci. 1998;62(16):PL271-6. doi: 10.1016/s0024-3205(98)00086-1.