PMID- 9585234
OWN - NLM
STAT- MEDLINE
DCOM- 19980529
LR  - 20220330
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 4
IP  - 5
DP  - 1998 May
TI  - Eradication of established murine tumors using a novel cell-free vaccine: 
      dendritic cell-derived exosomes.
PG  - 594-600
AB  - Dendritic cells (DCs) are professional antigen presenting cells with the unique 
      capacity to induce primary and secondary immune responses in vivo. Here, we show 
      that DCs secrete antigen presenting vesicles, called exosomes, which express 
      functional Major Histocompatibility Complex class I and class II, and T-cell 
      costimulatory molecules. Tumor peptide-pulsed DC-derived exosomes prime specific 
      cytotoxic T lymphocytes in vivo and eradicate or suppress growth of established 
      murine tumors in a T cell-dependent manner. Exosome-based cell-free vaccines 
      represent an alternative to DC adoptive therapy for suppressing tumor growth.
FAU - Zitvogel, L
AU  - Zitvogel L
AD  - CNRS URA 1301, Institut Gustave Roussy, Villejuif, France.
FAU - Regnault, A
AU  - Regnault A
FAU - Lozier, A
AU  - Lozier A
FAU - Wolfers, J
AU  - Wolfers J
FAU - Flament, C
AU  - Flament C
FAU - Tenza, D
AU  - Tenza D
FAU - Ricciardi-Castagnoli, P
AU  - Ricciardi-Castagnoli P
FAU - Raposo, G
AU  - Raposo G
FAU - Amigorena, S
AU  - Amigorena S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Cancer Vaccines)
RN  - 0 (H-2 Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Adenocarcinoma/immunology
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, Neoplasm/immunology
MH  - Cancer Vaccines/immunology/*therapeutic use
MH  - Cell-Free System
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - H-2 Antigens/genetics
MH  - Histocompatibility Antigens Class I
MH  - Histocompatibility Antigens Class II
MH  - Lymphocyte Activation
MH  - Mammary Neoplasms, Animal/immunology
MH  - Mast-Cell Sarcoma/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred DBA
MH  - Mice, Nude
MH  - Neoplasms, Experimental/immunology/*therapy
MH  - Peptide Fragments/immunology
MH  - Subcellular Fractions/*immunology
MH  - T-Lymphocytes, Cytotoxic/immunology
EDAT- 1998/05/19 00:00
MHDA- 1998/05/19 00:01
CRDT- 1998/05/19 00:00
PHST- 1998/05/19 00:00 [pubmed]
PHST- 1998/05/19 00:01 [medline]
PHST- 1998/05/19 00:00 [entrez]
AID - 10.1038/nm0598-594 [doi]
PST - ppublish
SO  - Nat Med. 1998 May;4(5):594-600. doi: 10.1038/nm0598-594.