PMID- 9585434
OWN - NLM
STAT- MEDLINE
DCOM- 19980622
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 9
IP  - 6
DP  - 1998 Jun
TI  - Cloning, characterization, and chromosomal assignment of the human ortholog of 
      murine Zfp-37, a candidate gene for Nager syndrome.
PG  - 458-62
AB  - In an effort to identify putative transcription factors involved in chondrocyte 
      differentiation during human endochondral bone formation, a human fetal 
      cartilage-specific cDNA library was screened with a degenerate oligonucleotide 
      probe corresponding to a conserved stretch of eight amino acids from the zinc 
      finger region of the Drosophila Kruppel gene family of DNA-binding proteins. 
      Using this strategy, we have identified a novel zinc finger gene ZFP-37. ZFP-37 
      corresponds to a putative transcription factor containing 12 tandemly repeated 
      zinc finger motifs and a Kruppel-associated box (KRAB) domain. The KRAB domain 
      has been reported to function as a transcriptional repressor and is located in 
      the amino terminus, while the zinc finger repeats are positioned at the 
      carboxy-terminal end of ZFP-37. Gene mapping with a somatic cell hybrid panel and 
      fluorescence in situ hybridization (FISH) localized ZFP-37 to human Chr 9q32. The 
      gene is expressed at low level as a 3.2-kb mRNA in several tissues including 
      fetal human cartilage. Sequence comparison revealed that ZFP-37 may represent the 
      human homolog of the mouse gene Zfp-37. The map location and expression pattern 
      suggest ZFP-37 as a candidate gene for a craniofacial-limb malformation, Nager 
      syndrome (acrofacial dysostosis).
FAU - Dreyer, S D
AU  - Dreyer SD
AD  - Children's Hospital, University of Mainz, Langenbeckstr. 1, D-55101 Mainz, 
      Germany.
FAU - Zhou, L
AU  - Zhou L
FAU - Machado, M A
AU  - Machado MA
FAU - Horton, W A
AU  - Horton WA
FAU - Zabel, B
AU  - Zabel B
FAU - Winterpacht, A
AU  - Winterpacht A
FAU - Lee, B
AU  - Lee B
LA  - eng
SI  - GENBANK/AF022158
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (ZFP37 protein, human)
RN  - 0 (Zfp37 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Craniofacial Dysostosis/*genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*genetics
MH  - Sequence Alignment
MH  - Syndrome
MH  - Transcription Factors/*genetics
MH  - *Zinc Fingers
EDAT- 1998/05/28 00:00
MHDA- 1998/05/28 00:01
CRDT- 1998/05/28 00:00
PHST- 1998/05/28 00:00 [pubmed]
PHST- 1998/05/28 00:01 [medline]
PHST- 1998/05/28 00:00 [entrez]
AID - 10.1007/s003359900796 [doi]
PST - ppublish
SO  - Mamm Genome. 1998 Jun;9(6):458-62. doi: 10.1007/s003359900796.